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    pan-1 P-granule-associated novel protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pan-1
    Official Full Name
    P-granule-associated novel protein 1
    Primary source
    WormBase:WBGene00003915
    Locus tag
    CELE_M88.6
    See related
    AllianceGenome:WB:WBGene00003915
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DEAD/H-box RNA helicase binding activity. Involved in germ cell development and molting cycle. Located in P granule and plasma membrane. Is expressed in several structures, including body wall musculature; gonad; hypodermis; intestine; and somatic nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pan-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (4562738..4566283)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene K Homology domain-containing protein Neighboring gene Malonyl-CoA decarboxylase, mitochondrial Neighboring gene Isocitrate dehydrogenase [NAD] subunit, mitochondrial Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling. Xia SL, et al. Elife, 2021 May 5. PMID 33950834, Free PMC Article
    2. The C. elegans gene pan-1 encodes novel transmembrane and cytoplasmic leucine-rich repeat proteins and promotes molting and the larva to adult transition. Gissendanner CR, et al. BMC Dev Biol, 2013 May 17. PMID 23682709, Free PMC Article
    3. PAN-1, a P-granule component important for C. elegans fertility, has dual roles in the germline and soma. Gao G, et al. Dev Biol, 2012 Apr 15. PMID 22342905
    4. Functional genomic analysis of C. elegans molting. Frand AR, et al. PLoS Biol, 2005 Oct. PMID 16122351, Free PMC Article
    5. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Hayes GD, et al. Development, 2006 Dec. PMID 17065234

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling.
      Title: The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling.
    2. This report demonstrated that, while loss of PAN-1 in the soma inhibits molting, PAN-1 is also a P-granule component that is essential for fertility.
      Title: PAN-1, a P-granule component important for C. elegans fertility, has dual roles in the germline and soma.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DEAD/H-box RNA helicase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    P-granule-associated novel protein 1
    NP_001293622.1
    • Partially confirmed by transcript evidence
    NP_497924.2
    • Confirmed by transcript evidence
    NP_497925.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4562738..4566283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065524.6 → NP_497925.1  P-granule-associated novel protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497925.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21604, Q9U3A0, S6FWR2
      Conserved Domains (3) summary
      cd00116
      Location:80 → 326
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:130 → 152
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:199 → 259
      LRR_8; Leucine rich repeat

    2. NM_065523.8 → NP_497924.2  P-granule-associated novel protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497924.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3A0
      Conserved Domains (4) summary
      cd00116
      Location:11 → 125
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:12 → 35
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:34 → 83
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:11 → 78
      LRR_8; Leucine rich repeat

    3. NM_001306693.3 → NP_001293622.1  P-granule-associated novel protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3A0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U3A0.1

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