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    T02C1.2 RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 176306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T02C1.2
    Official Full Name
    RING-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00011366
    Locus tag
    CELE_T02C1.2
    See related
    AllianceGenome:WB:WBGene00011366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleosome binding activity and ubiquitin-protein transferase activity. Predicted to be involved in double-strand break repair. Predicted to be located in membrane. Predicted to be active in nucleus and site of double-strand break. Orthologous to human RNF169 (ring finger protein 169). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T02C1.2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (9251029..9253126)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Sodium-dependent dopamine transporter Neighboring gene putative RING finger protein T02C1.1 Neighboring gene Uncharacterized protein Neighboring gene CAP-Gly domain-containing linker protein 1 homolog Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RING-type E3 ubiquitin transferase
    NP_001022740.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9251029..9253126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027569.4 → NP_001022740.2  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022740.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YWU1
      Conserved Domains (2) summary
      cd00162
      Location:100 → 137
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl17238
      Location:96 → 137
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version

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