wsp-1 CRIB domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wsp-1
Official Full Name: CRIB domain-containing protein
Primary source: WormBase:WBGene00006957
Locus tag: CELE_C07G1.4
See related: AllianceGenome:WB:WBGene00006957
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cytoskeletal regulatory protein binding activity and small GTPase binding activity. Involved in several processes, including embryonic morphogenesis; positive regulation of clathrin-dependent endocytosis; and positive regulation of egg-laying behavior. Located in cell leading edge; cortical actin cytoskeleton; and presynaptic periactive zone. Is expressed in several structures, including Q cell; anchor cell; epithelial cell; hypodermis; and ventral nerve cord. Orthologous to human WASL (WASP like actin nucleation promoting factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See wsp-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (8188904..8198951, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Redox-sensitive CDC-42 clustering promotes wound closure in C. elegans.
Title: Redox-sensitive CDC-42 clustering promotes wound closure in C. elegans.
there is a link between RBR-2 activity, H3K4me3 levels, the NURF complex and the expression of WSP-1
Title: The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1.
genetic and pharmacological evidence that WSP-1 plays an essential role to stabilize the actin cytoskeleton at the neuronal active zone of the neuromuscular junction to restrain synaptic vesicle release
Title: Caenorhabditis elegans wsp-1 regulation of synaptic function at the neuromuscular junction.
WH2-domain-containing activators of the Arp2/3 complex, WVE-1/WAVE and WSP-1/WASP, act redundantly in axon guidance
Title: The Arp2/3 activators WAVE and WASP have distinct genetic interactions with Rac GTPases in Caenorhabditis elegans axon guidance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C07G1.4 (e-PCR)
- UniSTS:308988

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal regulatory protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	IC Inferred by Curator more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic ectodermal digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic ectodermal digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microvillus organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microvillus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of egg-laying behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in presynaptic periactive zone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CRIB domain-containing protein

NP_001379549.1

Confirmed by transcript evidence

NP_741459.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8188904..8198951 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171393.8 → NP_741459.2 CRIB domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741459.2

Status: REVIEWED

UniProtKB/TrEMBL

Q17795

Conserved Domains (3) summary

pfam00786
Location:258 → 317

PBD; P21-Rho-binding domain

pfam02205
Location:499 → 525

WH2; WH2 motif

cl17171
Location:45 → 150

PH-like; Pleckstrin homology-like domain
NM_001392345.1 → NP_001379549.1 CRIB domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQE6

Conserved Domains (3) summary

pfam00786
Location:432 → 494

PBD; P21-Rho-binding domain

cd22070
Location:673 → 694

WH2_Pan1-like; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) domain found in Actin cytoskeleton-regulatory complex protein Pan1, and similar proteins

cd22072
Location:705 → 733

WH2_WAVE-2; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 2 (WASP2 or WAVE2 or WASF2 or SCAR2)