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    rig-4 Protein sidekick homolog [ Caenorhabditis elegans ]

    Gene ID: 177597, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rig-4
    Official Full Name
    Protein sidekick homolog
    Primary source
    WormBase:WBGene00004371
    Locus tag
    CELE_Y42H9B.2
    See related
    AllianceGenome:WB:WBGene00004371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse assembly. Predicted to be located in membrane. Predicted to be active in synapse. Is expressed in several structures, including DA neuron; excretory cell; nerve ring neurons; spermathecal-uterine junction; and vulva. Orthologous to human SDK1 (sidekick cell adhesion molecule 1) and SDK2 (sidekick cell adhesion molecule 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See rig-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (7991410..8004119, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Col_cuticle_N domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. Ziel JW, et al. Nat Cell Biol, 2009 Feb. PMID 19098902, Free PMC Article
    2. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein sidekick homolog
    NP_501339.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7991410..8004119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068938.9 → NP_501339.2  Protein sidekick homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501339.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N3X8
      Conserved Domains (5) summary
      cd00096
      Location:564 → 635
      Ig; Immunoglobulin domain
      smart00408
      Location:478 → 534
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:330 → 402
      IG_like; Immunoglobulin like
      cd00063
      Location:1156 → 1251
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:459 → 543
      I-set; Immunoglobulin I-set domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N3X8.2

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