let-19 Mediator of RNA polymerase II transcription subunit 13 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: let-19
Official Full Name: Mediator of RNA polymerase II transcription subunit 13
Primary source: WormBase:WBGene00002295
Locus tag: CELE_K08F8.6
See related: AllianceGenome:WB:WBGene00002295
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of mediator complex. Is expressed in several structures, including TL.a; TL.p; TR.a; hypodermis; and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and dextro-looped transposition of the great arteries. Orthologous to human MED13 (mediator complex subunit 13) and MED13L (mediator complex subunit 13L). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See let-19 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 20

Sequence:: Chromosome: II; NC_003280.10 (8770975..8782020)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LET-19 and DPY-22 in the Mediator complex repress the transcription of Wnt target genes and are required for asymmetric cell division.
Title: Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K08F8.6 (e-PCR)
- UniSTS:311485

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mediator of RNA polymerase II transcription subunit 13

NP_495866.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8770975..8782020

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063465.5 → NP_495866.2 Mediator of RNA polymerase II transcription subunit 13 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495866.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93442, Q93863

Conserved Domains (3) summary

pfam06333
Location:2487 → 2848

Med13_C; Mediator complex subunit 13 C-terminal

pfam07777
Location:1198 → 1259

MFMR; G-box binding protein MFMR

pfam11597
Location:31 → 564

Med13_N; Mediator complex subunit 13 N-terminal