cki-1 Cyclin-dependent kinase inhibitor 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cki-1
Official Full Name: Cyclin-dependent kinase inhibitor 1
Primary source: WormBase:WBGene00000516
Locus tag: CELE_T05A6.1
See related: AllianceGenome:WB:WBGene00000516
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including gonad development; regulation of cell cycle process; and regulation of cell division. Located in nucleus. Is expressed in several structures, including excretory duct; hermaphrodite somatic gonadal cell; hypodermal cell; pharynx; and somatic gonad precursor. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cki-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 2

Sequence:: Chromosome: II; NC_003280.10 (7811240..7812105)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data also suggest that integrin plays a major role in maintaining proper CKI-1/p27(KIP1) levels in the cell.
Title: A novel mutation in β integrin reveals an integrin-mediated interaction between the extracellular matrix and cki-1/p27KIP1.
BRAP-2 is necessary for preventing an inappropriate response to elevated levels of reactive oxygen species by countering premature activation of BRC-1 and CKI-1.
Title: Developmental arrest of Caenorhabditis elegans BRAP-2 mutant exposed to oxidative stress is dependent on BRC-1.
Both cki-1 and cki-2 mediate cell cycle quiescence, but our genetic and phenotypic analyses demonstrate that they act within distinct pathways to exert control over the cell cycle machinery.
Title: The cyclin-dependent kinase inhibitors, cki-1 and cki-2, act in overlapping but distinct pathways to control cell cycle quiescence during C. elegans development.
CKI-1 cyclin-dependent kinase inhibitor has an essential embryonic role in cell cycle exit and morphogenesis.
Title: Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans.
cki-1 is required to ensure the proper formation ans specification of the gonadal sheath cell precursors.
Title: cki-1 links cell division and cell fate acquisition in the C. elegans somatic gonad.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T05A6.1 (e-PCR)
- UniSTS:318412

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G1 to G0 transition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of G1 to G0 transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA endoreduplication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle G1/S phase transition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell division	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cyclin-dependent kinase inhibitor 1

NP_495641.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7811240..7812105

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063240.5 → NP_495641.1 Cyclin-dependent kinase inhibitor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495641.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22197

Conserved Domains (1) summary

pfam02234
Location:7 → 52

CDI; Cyclin-dependent kinase inhibitor