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    slc-36.5 Amino acid transporter transmembrane domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc-36.5
    Official Full Name
    Amino acid transporter transmembrane domain-containing protein
    Primary source
    WormBase:WBGene00016628
    Locus tag
    CELE_C44B7.6
    See related
    AllianceGenome:WB:WBGene00016628
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in membrane. Predicted to be active in vacuolar membrane. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See slc-36.5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (6872827..6877057, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Calcium homeostasis modulator protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene gamma-glutamylcyclotransferase Neighboring gene ABC transporter domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    2. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Amino acid transporter transmembrane domain-containing protein
    NP_001022026.1
    • Confirmed by transcript evidence
    NP_001022027.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6872827..6877057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026855.6 → NP_001022026.1  Amino acid transporter transmembrane domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18595
      Conserved Domains (1) summary
      cl00456
      Location:75 → 481
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001026856.3 → NP_001022027.1  Amino acid transporter transmembrane domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KY81
      Conserved Domains (1) summary
      cl00456
      Location:21 → 426
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version

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