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    oga-1 GH84 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181164, updated on 9-Dec-2024

    Summary

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    Official Symbol
    oga-1
    Official Full Name
    GH84 domain-containing protein
    Primary source
    WormBase:WBGene00020596
    Locus tag
    CELE_T20B5.3
    See related
    AllianceGenome:WB:WBGene00020596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables hexosaminidase activity and protein serine/threonine phosphatase activity. Involved in several processes, including dauer larval development; glycogen metabolic process; and negative regulation of protein glycosylation. Is expressed in several structures, including coelomocyte; nervous system; non-striated muscle; rectal muscle; and reproductive system. Used to study type 2 diabetes mellitus. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See oga-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (9343333..9347430, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene AP-2 complex subunit alpha Neighboring gene FMRF-Like Peptide Neighboring gene Protein kinase C;Protein kinase C-like 2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans hyaluronidase: a developmentally significant enzyme with chondroitin-degrading activity at both acidic and neutral pH. Chatel A, et al. Matrix Biol, 2010 Jul. PMID 20576486
    2. Phenotyping of the thrashing forces exerted by partially immobilized C. elegans using elastomeric micropillar arrays. Sofela S, et al. Lab Chip, 2019 Nov 7. PMID 31576392
    3. Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer. Forsythe ME, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16882729, Free PMC Article
    4. Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Love DC, et al. Proc Natl Acad Sci U S A, 2010 Apr 20. PMID 20368426, Free PMC Article
    5. Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans. Rahman MM, et al. Aging (Albany NY), 2010 Oct. PMID 20952811, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that glucose stress, oga-1 mutants, and ogt-1 mutants each result in an increase in daf-2 carbohydrate storage.
      Title: O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans.
    2. a C. elegans oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer
      Title: Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-N-acetylglucosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-N-acetylglucosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate derivative metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycoprotein metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GH84 domain-containing protein
    NP_001123183.1
    • Confirmed by transcript evidence
    NP_001123184.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9343333..9347430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129711.3 → NP_001123183.1  GH84 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1WBU7, Q1WBU8
      Conserved Domains (1) summary
      pfam07555
      Location:20 → 294
      NAGidase; beta-N-acetylglucosaminidase

    2. NM_001129712.4 → NP_001123184.1  GH84 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WFI7, Q1WBU9
      Conserved Domains (2) summary
      pfam07555
      Location:20 → 306
      NAGidase; beta-N-acetylglucosaminidase
      cl00259
      Location:730 → 794
      Sm_like; Sm and related proteins
    Nucleotide Protein
    Heading Accession and Version

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