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    • Showing Current items.

    dhhc-2 Palmitoyltransferase [ Caenorhabditis elegans ]

    Gene ID: 173062, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhhc-2
    Official Full Name
    Palmitoyltransferase
    Primary source
    WormBase:WBGene00012948
    Locus tag
    CELE_Y47H9C.2
    See related
    AllianceGenome:WB:WBGene00012948
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Raymond type. Orthologous to several human genes including ZDHHC18 (zinc finger DHHC-type palmitoyltransferase 18) and ZDHHC9 (zinc finger DHHC-type palmitoyltransferase 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhhc-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (11836460..11849258)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene CUB_2 domain-containing protein Neighboring gene ncRNA Neighboring gene Cell death abnormality protein 1 Neighboring gene ncRNA Neighboring gene DnaJ homolog subfamily C member 10;Thioredoxin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A systematic analysis of protein palmitoylation in Caenorhabditis elegans. Edmonds MJ, et al. BMC Genomics, 2014 Oct 2. PMID 25277130, Free PMC Article
    2. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Palmitoyltransferase
    NP_493007.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11836460..11849258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060606.6 → NP_493007.2  Palmitoyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493007.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWD7
      Conserved Domains (1) summary
      cl19890
      Location:72 → 319
      zf-DHHC; DHHC palmitoyltransferase
    Nucleotide Protein
    Heading Accession and Version

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