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    hen-1 HEsitatioN behavior [ Caenorhabditis elegans ]

    Gene ID: 191666, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hen-1
    Official Full Name
    HEsitatioN behavior
    Primary source
    WormBase:WBGene00001841
    Locus tag
    CELE_C36B7.7
    See related
    AllianceGenome:WB:WBGene00001841
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including associative learning; dauer larval development; and sensory processing. Located in axon and neuronal cell body. Is expressed in neurons; pharyngeal muscle cell; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hen-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (7116202..7116996, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene dual-specificity kinase Neighboring gene ncRNA Neighboring gene IRS-type PTB domain-containing protein Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene Aldehyde dehydrogenase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A neuropeptide signal confers ethanol state dependency during olfactory learning in Caenorhabditis elegans. Lindsay JH, et al. Proc Natl Acad Sci U S A, 2022 Nov 16. PMID 36343256, Free PMC Article
    2. Molecular physiology of the neural circuit for calcineurin-dependent associative learning in Caenorhabditis elegans. Kuhara A, et al. J Neurosci, 2006 Sep 13. PMID 16971519, Free PMC Article
    3. Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans. Kamminga LM, et al. PLoS Genet, 2012. PMID 22829772, Free PMC Article
    4. HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans. Ishihara T, et al. Cell, 2002 May 31. PMID 12062106
    5. Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegans. Chi CA, et al. J Exp Biol, 2007 Nov. PMID 17981872

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Global gene expression analysis of henn-1 mutants reveals mild effects, including down-regulation of many germline-expressed genes.
      Title: Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans.
    2. henn-1 is likely to have important roles in RNA silencing pathways throughout C. elegans development.
      Title: PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transmembrane receptor protein tyrosine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of chemical stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory perception of chemical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HEsitatioN behavior
    NP_509200.1
    • Product from WormBase gene class hen;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7116202..7116996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076799.7 → NP_509200.1  HEsitatioN behavior [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECA8
    Nucleotide Protein
    Heading Accession and Version

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