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    • Showing Current items.

    lys-1 Lysozyme-like protein 1 [ Caenorhabditis elegans ]

    Gene ID: 179428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lys-1
    Official Full Name
    Lysozyme-like protein 1
    Primary source
    WormBase:WBGene00003090
    Locus tag
    CELE_Y22F5A.4
    See related
    AllianceGenome:WB:WBGene00003090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and innate immune response. Located in apical part of cell and cytoplasmic vesicle. Is expressed in intestine and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lys-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (10277904..10279056)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Lysozyme-like protein 2 Neighboring gene Lysozyme-like protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tasco®: a product of Ascophyllum nodosum enhances immune response of Caenorhabditis elegans against Pseudomonas aeruginosa infection. Kandasamy S, et al. Mar Drugs, 2012 Jan. PMID 22363222, Free PMC Article
    2. Characterizing the type 6 secretion system (T6SS) of E. cloacae SBP-8 and its role in pathogenesis and bacterial competition. Khan S, et al. Microb Pathog, 2023 Oct. PMID 37536636
    3. Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals. Zhang L, et al. Arch Pharm Res, 2023 Jul. PMID 37535304
    4. Elucidating the pathogenic potential of Enterobacter cloacae SBP-8 using Caenorhabditis elegans as a model host. Khan S, et al. Microb Pathog, 2020 Nov. PMID 32798671
    5. Antimicrobial proteins in the response to graphene oxide in Caenorhabditis elegans. Ren M, et al. Nanotoxicology, 2017 May. PMID 28490217

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response HEP PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lysozyme-like protein 1
    NP_505642.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10277904..10279056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073241.7 → NP_505642.1  Lysozyme-like protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505642.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62415
      Conserved Domains (1) summary
      cd06416
      Location:60 → 262
      GH25_Lys1-like; Lys-1 is a lysozyme encoded by the Caenorhabditis elegans lys-1 gene. This gene is one of a several lysozyme genes upregulated upon infection by the Gram-negative bacterial pathogen Serratia marcescens. Lys-1 contains a glycosyl hydrolase family 25 ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62415.1

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