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    tgt-2 Queuine tRNA-ribosyltransferase accessory subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 180244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tgt-2
    Official Full Name
    Queuine tRNA-ribosyltransferase accessory subunit 2
    Primary source
    WormBase:WBGene00006567
    Locus tag
    CELE_Y39B6A.35
    See related
    AllianceGenome:WB:WBGene00006567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity and tRNA-guanosine(34) queuine transglycosylase activity. Predicted to be involved in tRNA-guanine transglycosylation. Predicted to be located in cytoplasm. Is expressed in intestine and nervous system. Orthologous to human QTRT2 (queuine tRNA-ribosyltransferase accessory subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tgt-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (18998345..19000918)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Structural protein Neighboring gene General transcription factor IIF subunit 2 Neighboring gene APOPT family protein Y39B6A.34, mitochondrial;COA8 family protein Y39B6A.34, mitochondrial Neighboring gene Ribosome biogenesis protein NOP53

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-guanine transglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA-guanine transglycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Queuine tRNA-ribosyltransferase accessory subunit 2
    NP_741662.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18998345..19000918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171572.4 → NP_741662.1  Queuine tRNA-ribosyltransferase accessory subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741662.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NEU3
      Conserved Domains (2) summary
      COG0343
      Location:4 → 369
      Tgt; Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]
      pfam01702
      Location:149 → 369
      TGT; Queuine tRNA-ribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NEU3.1

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