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    cyp-35A1 CYtochrome P450 family [ Caenorhabditis elegans ]

    Gene ID: 182176, updated on 9-Dec-2024

    Summary

    Official Symbol
    cyp-35A1
    Official Full Name
    CYtochrome P450 family
    Primary source
    WormBase:WBGene00015399
    Locus tag
    CELE_C03G6.14
    See related
    AllianceGenome:WB:WBGene00015399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); drug dependence (multiple); gastrointestinal system cancer (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2D6 (cytochrome P450 family 2 subfamily D member 6); and CYP2E1 (cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See cyp-35A1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (7359929..7361773, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene CYtochrome P450 family Neighboring gene Excretory canal abnormal exc-13

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in organic acid metabolic process  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in xenobiotic metabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in intracellular membrane-bounded organelle  

    General protein information

    Preferred Names
    CYtochrome P450 family
    NP_001343612.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7359929..7361773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356694.2NP_001343612.1  CYtochrome P450 family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02627
      Conserved Domains (1) summary
      cl12078
      Location:26466
      p450; Cytochrome P450
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