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    gtsf-1 CHHC U11-48K-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178471, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gtsf-1
    Official Full Name
    CHHC U11-48K-type domain-containing protein
    Primary source
    WormBase:WBGene00020286
    Locus tag
    CELE_T06A10.3
    See related
    AllianceGenome:WB:WBGene00020286
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Located in cytoplasm. Is expressed in germ line. Orthologous to human GTSF1 (gametocyte specific factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gtsf-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (16865840..16866504)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase;Helicase C-terminal domain-containing protein Neighboring gene ING family member lsy-13 Neighboring gene Uncharacterized protein Neighboring gene Sodium:proton antiporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GTSF-1 is required for formation of a functional RNA-dependent RNA Polymerase complex in Caenorhabditis elegans. Almeida MV, et al. EMBO J, 2018 Jun 15. PMID 29769402, Free PMC Article
    2. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Thivierge C, et al. Nat Struct Mol Biol, 2011 Dec 18. PMID 22179787, Free PMC Article
    3. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine TF, et al. Cell, 2006 Jan 27. PMID 16439208
    4. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
    5. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GTSF-1 homologs may act to drive the assembly of larger complexes that act in sRNA production and/or in imposing sRNA-mediated silencing activities.
      Title: GTSF-1 is required for formation of a functional RNA-dependent RNA Polymerase complex in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    CHHC U11-48K-type domain-containing protein
    NP_001299961.1
    • Confirmed by transcript evidence
    NP_001368542.1
    • Confirmed by transcript evidence
    NP_503000.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      16865840..16866504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070599.3 → NP_503000.1  CHHC U11-48K-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3QMD6
      Conserved Domains (1) summary
      pfam05253
      Location:56 → 79
      zf-U11-48K; U11-48K-like CHHC zinc finger

    2. NM_001380561.1 → NP_001368542.1  CHHC U11-48K-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARJ4
      Conserved Domains (1) summary
      pfam05253
      Location:26 → 49
      zf-U11-48K; U11-48K-like CHHC zinc finger

    3. NM_001313032.3 → NP_001299961.1  CHHC U11-48K-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AV29
    Nucleotide Protein
    Heading Accession and Version

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