dnj-14 J domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: dnj-14
Official Full Name: J domain-containing protein
Primary source: WormBase:WBGene00001032
Locus tag: CELE_K02G10.8
See related: AllianceGenome:WB:WBGene00001032
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in determination of adult lifespan; locomotion; and neurotransmitter secretion. Predicted to be located in membrane. Predicted to be active in type Is terminal bouton. Used to study neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 4. Orthologous to several human genes including DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5) and DNAJC5B (DnaJ heat shock protein family (Hsp40) member C5 beta). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Tissue distribution of cysteine string protein/DNAJC5 in C. elegans analysed by CRISPR/Cas9-mediated tagging of endogenous DNJ-14.
Title: Tissue distribution of cysteine string protein/DNAJC5 in C. elegans analysed by CRISPR/Cas9-mediated tagging of endogenous DNJ-14.
This study has revealed a genetic interaction between dnj-14 and ubiquitin proteasome system regulation resulting in down-regulation of multiple E3 ligase components and decreased ubiquitylated protein degradation.
Title: Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components.
Mutant dnj-14 worms also exhibited age-dependent neurodegeneration of sensory neurons.
Title: Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.

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Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuromuscular synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in type Is terminal bouton	IBA Inferred from Biological aspect of Ancestor more info