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    C24G6.8 putative peptidyl-tRNA hydrolase 2 [ Caenorhabditis elegans ]

    Gene ID: 178937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C24G6.8
    Official Full Name
    putative peptidyl-tRNA hydrolase 2
    Primary source
    WormBase:WBGene00016062
    Locus tag
    CELE_C24G6.8
    See related
    AllianceGenome:WB:WBGene00016062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aminoacyl-tRNA hydrolase activity. Predicted to be active in cytosol and mitochondrion. Orthologous to human PTRH2 (peptidyl-tRNA hydrolase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C24G6.8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (5534118..5535874, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene receptor protein-tyrosine kinase Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein Neighboring gene Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 1 Neighboring gene Cystic Fibrosis Transmembrane conductance regulator homolog Neighboring gene Putative UDP-glucuronosyltransferase ugt-48

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion. Tzur YB, et al. PLoS Biol, 2012. PMID 22927794, Free PMC Article
    2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative peptidyl-tRNA hydrolase 2
    NP_001367534.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5534118..5535874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380643.2 → NP_001367534.1  putative peptidyl-tRNA hydrolase 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76387
      Conserved Domains (2) summary
      cd02430
      Location:201 → 316
      PTH2; Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in ...
      cl21463
      Location:128 → 171
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76387.1

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