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    ncap-1 NECAP PHear domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncap-1
    Official Full Name
    NECAP PHear domain-containing protein
    Primary source
    WormBase:WBGene00022453
    Locus tag
    CELE_Y110A2AR.3
    See related
    AllianceGenome:WB:WBGene00022453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in vesicle-mediated transport. Predicted to be located in membrane. Predicted to be part of clathrin vesicle coat. Is expressed in nerve ring. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 21. Orthologous to human NECAP1 (NECAP endocytosis associated 1) and NECAP2 (NECAP endocytosis associated 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ncap-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (2913705..2919314, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene E2 ubiquitin-conjugating enzyme Neighboring gene E2 ubiquitin-conjugating enzyme;UBIQUITIN_CONJUGAT_2 domain-containing protein Neighboring gene Receptor expression-enhancing protein Neighboring gene DUF1084 domain-containing protein;G protein-coupled receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex. Partlow EA, et al. Elife, 2019 Aug 29. PMID 31464684, Free PMC Article
    2. NECAPs are negative regulators of the AP2 clathrin adaptor complex. Beacham GM, et al. Elife, 2018 Jan 18. PMID 29345618, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NECAP PHear domain-containing protein
    NP_001380057.1
    • Confirmed by transcript evidence
    NP_494398.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2913705..2919314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061997.6 → NP_494398.1  NECAP PHear domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N489
      Conserved Domains (1) summary
      pfam07933
      Location:4 → 158
      DUF1681; Protein of unknown function (DUF1681)

    2. NM_001393026.1 → NP_001380057.1  NECAP PHear domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0S9
      Conserved Domains (1) summary
      cl17171
      Location:4 → 61
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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