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    ipp-5 inositol-polyphosphate 5-phosphatase;putative type I inositol 1,4,5-trisphosphate 5-phosphatase [ Caenorhabditis elegans ]

    Gene ID: 180871, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ipp-5
    Official Full Name
    inositol-polyphosphate 5-phosphatase;putative type I inositol 1,4,5-trisphosphate 5-phosphatase
    Primary source
    WormBase:WBGene00002146
    Locus tag
    CELE_C09B8.1
    See related
    AllianceGenome:WB:WBGene00002146
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable inositol-polyphosphate 5-phosphatase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and ovulation. Is expressed in spermatheca. Orthologous to human INPP5A (inositol polyphosphate-5-phosphatase A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ipp-5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (6031469..6034515)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 53 Neighboring gene F-box C protein Neighboring gene SHSP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inositol polyphosphate multikinase IPMK-1 regulates development through IP3/calcium signaling in Caenorhabditis elegans. Yang ZL, et al. Cell Calcium, 2021 Jan. PMID 33316585
    2. The Flightless I homolog, fli-1, regulates anterior/posterior polarity, asymmetric cell division and ovulation during Caenorhabditis elegans development. Deng H, et al. Genetics, 2007 Oct. PMID 17720906, Free PMC Article
    3. The DSL ligand APX-1 is required for normal ovulation in C. elegans. McGovern M, et al. Dev Biol, 2018 Mar 15. PMID 29371032, Free PMC Article
    4. HLH-29 regulates ovulation in C. elegans by targeting genes in the inositol triphosphate signaling pathway. White A, et al. Biol Open, 2012 Mar 15. PMID 23213416, Free PMC Article
    5. Regulation of maternal phospholipid composition and IP(3)-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans. Kniazeva M, et al. Genes Dev, 2012 Mar 15. PMID 22426533, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol phosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-polyphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-polyphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ovulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inositol-polyphosphate 5-phosphatase;putative type I inositol 1,4,5-trisphosphate 5-phosphatase
    NP_001348790.1
    • Confirmed by transcript evidence
    NP_509008.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6031469..6034515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001361812.4 → NP_001348790.1  inositol-polyphosphate 5-phosphatase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5AU07
      Conserved Domains (1) summary
      cl00490
      Location:2 → 408
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. NM_076607.9 → NP_509008.2  putative type I inositol 1,4,5-trisphosphate 5-phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509008.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17848, Q8WRS7
      Conserved Domains (1) summary
      cd09092
      Location:2 → 409
      INPP5A; Type I inositol polyphosphate 5-phosphatase I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17848.2

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