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    lea-1 Plant Late Embryo Abundant (LEA) related [ Caenorhabditis elegans ]

    Gene ID: 3564838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lea-1
    Official Full Name
    Plant Late Embryo Abundant (LEA) related
    Primary source
    WormBase:WBGene00002263
    Locus tag
    CELE_K08H10.1
    See related
    AllianceGenome:WB:WBGene00002263
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lipid binding activity. Involved in hyperosmotic response; response to desiccation; and response to heat. Predicted to be located in extracellular region. Is expressed in several structures, including excretory cell; germ line; head; intestine; and tail neurons. Orthologous to human PLIN4 (perilipin 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lea-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    12
    Sequence:
    Chromosome: V; NC_003283.11 (10011923..10028168)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nucleoside-diphosphatase uda-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase;Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential gene expression during desiccation stress in the insect-killing nematode Steinernema feltiae IS-6. Gal TZ, et al. J Parasitol, 2003 Aug. PMID 14533688
    2. Desiccation-induced structuralization and glass formation of group 3 late embryogenesis abundant protein model peptides. Shimizu T, et al. Biochemistry, 2010 Feb 16. PMID 20028138
    3. Accumulation of Glycogen and Upregulation of LEA-1 in C. elegans daf-2(e1370) Support Stress Resistance, Not Longevity. Zečić A, et al. Cells, 2022 Jan 12. PMID 35053361, Free PMC Article
    4. LEA motifs promote desiccation tolerance in vivo. Hibshman JD, et al. BMC Biol, 2021 Dec 14. PMID 34903234, Free PMC Article
    5. An LEA group 3 family member is involved in survival of C. elegans during exposure to stress. Gal TZ, et al. FEBS Lett, 2004 Nov 5. PMID 15527756

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LEA motifs promote desiccation tolerance in vivo.
      Title: LEA motifs promote desiccation tolerance in vivo.
    2. Accumulation of Glycogen and Upregulation of LEA-1 in C. elegans daf-2(e1370) Support Stress Resistance, Not Longevity.
      Title: Accumulation of Glycogen and Upregulation of LEA-1 in C. elegans daf-2(e1370) Support Stress Resistance, Not Longevity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to desiccation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to desiccation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Plant Late Embryo Abundant (LEA) related
    NP_001256160.1
    • Confirmed by transcript evidence
    NP_001256161.1
    • Confirmed by transcript evidence
    NP_001256162.1
    • Confirmed by transcript evidence
    NP_001256163.1
    • Confirmed by transcript evidence
    NP_001256164.1
    • Confirmed by transcript evidence
    NP_001256165.1
    • Confirmed by transcript evidence
    NP_001256169.1
    • Confirmed by transcript evidence
    NP_001256170.1
    • Confirmed by transcript evidence
    NP_001256171.1
    • Confirmed by transcript evidence
    NP_001256173.1
    • Confirmed by transcript evidence
    NP_001256174.1
    • Confirmed by transcript evidence
    NP_001360513.1
    • Confirmed by transcript evidence
    NP_001360514.1
    • Confirmed by transcript evidence
    NP_001360515.1
    • Confirmed by transcript evidence
    NP_001360516.1
    • Confirmed by transcript evidence
    NP_001360517.1
    • Confirmed by transcript evidence
    NP_001360518.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10011923..10028168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373086.2 → NP_001360514.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WVD1
      Conserved Domains (2) summary
      PTZ00121
      Location:760 → 1269
      PTZ00121; MAEBL; Provisional
      pfam01442
      Location:275 → 458
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    2. NM_001373085.2 → NP_001360513.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WUR9
      Conserved Domains (2) summary
      PTZ00121
      Location:452 → 1141
      PTZ00121; MAEBL; Provisional
      PRK05035
      Location:1060 → 1294
      PRK05035; electron transport complex protein RnfC; Provisional

    3. NM_001269232.3 → NP_001256161.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLK7
      Conserved Domains (2) summary
      pfam01442
      Location:821 → 989
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl01888
      Location:761 → 830
      DUF883; Bacterial protein of unknown function (DUF883)

    4. NM_001269231.3 → NP_001256160.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256160.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLL1
      Conserved Domains (2) summary
      pfam01442
      Location:945 → 1113
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl01888
      Location:885 → 954
      DUF883; Bacterial protein of unknown function (DUF883)

    5. NM_001269233.4 → NP_001256162.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLK5
      Conserved Domains (1) summary
      pfam01442
      Location:214 → 371
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    6. NM_001269234.3 → NP_001256163.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLK8
      Conserved Domains (2) summary
      pfam01442
      Location:929 → 1097
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl01888
      Location:869 → 938
      DUF883; Bacterial protein of unknown function (DUF883)

    7. NM_001373087.2 → NP_001360515.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WVH0
      Conserved Domains (2) summary
      PTZ00121
      Location:436 → 1125
      PTZ00121; MAEBL; Provisional
      PRK05035
      Location:1044 → 1278
      PRK05035; electron transport complex protein RnfC; Provisional

    8. NM_001373088.2 → NP_001360516.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WWP8
      Conserved Domains (2) summary
      PTZ00121
      Location:744 → 1253
      PTZ00121; MAEBL; Provisional
      pfam01442
      Location:259 → 442
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    9. NM_001269235.3 → NP_001256164.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256164.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLK9
      Conserved Domains (2) summary
      pfam01442
      Location:805 → 973
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl01888
      Location:745 → 814
      DUF883; Bacterial protein of unknown function (DUF883)

    10. NM_001269236.3 → NP_001256165.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256165.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLK3
      Conserved Domains (1) summary
      pfam01442
      Location:198 → 355
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    11. NM_001269242.2 → NP_001256171.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256171.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFU3
      Conserved Domains (1) summary
      pfam01442
      Location:126 → 283
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    12. NM_001269241.4 → NP_001256170.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256170.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDH9
      Conserved Domains (2) summary
      pfam01442
      Location:733 → 901
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl01888
      Location:673 → 742
      DUF883; Bacterial protein of unknown function (DUF883)

    13. NM_001269240.3 → NP_001256169.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEF0
      Conserved Domains (2) summary
      pfam01442
      Location:857 → 1025
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl01888
      Location:797 → 866
      DUF883; Bacterial protein of unknown function (DUF883)

    14. NM_001373089.2 → NP_001360517.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WXP6
      Conserved Domains (2) summary
      PTZ00121
      Location:364 → 1053
      PTZ00121; MAEBL; Provisional
      PRK05035
      Location:972 → 1206
      PRK05035; electron transport complex protein RnfC; Provisional

    15. NM_001373090.2 → NP_001360518.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WTP6
      Conserved Domains (1) summary
      PTZ00121
      Location:672 → 1181
      PTZ00121; MAEBL; Provisional

    16. NM_001269244.3 → NP_001256173.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256173.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBW6
      Conserved Domains (2) summary
      pfam01442
      Location:104 → 272
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl01888
      Location:44 → 113
      DUF883; Bacterial protein of unknown function (DUF883)

    17. NM_001269245.3 → NP_001256174.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256174.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGB8
      Conserved Domains (2) summary
      pfam01442
      Location:104 → 272
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl01888
      Location:44 → 113
      DUF883; Bacterial protein of unknown function (DUF883)
    Nucleotide Protein
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