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    tli-1 CUE domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172936, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tli-1
    Official Full Name
    CUE domain-containing protein
    Primary source
    WormBase:WBGene00006578
    Locus tag
    CELE_F25H2.1
    See related
    AllianceGenome:WB:WBGene00006578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin binding activity and ubiquitin conjugating enzyme binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including anal depressor muscle; hypodermis; intestine; nervous system; and reproductive system. Orthologous to human TOLLIP (toll interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tli-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (10536115..10538088, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene MARVEL domain-containing protein Neighboring gene Sorting nexin-27 Neighboring gene ANK_REP_REGION domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-throughput in vivo analysis of gene expression in Caenorhabditis elegans. Hunt-Newbury R, et al. PLoS Biol, 2007 Sep. PMID 17850180, Free PMC Article
    2. Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Nicholas HR, et al. Mol Immunol, 2004 Jul. PMID 15183927
    3. Molecular definitions of autophagy and related processes. Galluzzi L, et al. EMBO J, 2017 Jul 3. PMID 28596378, Free PMC Article
    4. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CUE domain-containing protein
    NP_492757.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10536115..10538088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060356.4 → NP_492757.2  CUE domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492757.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93565
      Conserved Domains (2) summary
      cd04016
      Location:51 → 171
      C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)
      cd14363
      Location:196 → 236
      CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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