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    ctf-4 Minichromosome loss protein Mcl1 middle region domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctf-4
    Official Full Name
    Minichromosome loss protein Mcl1 middle region domain-containing protein
    Primary source
    WormBase:WBGene00008921
    Locus tag
    CELE_F17C11.10
    See related
    AllianceGenome:WB:WBGene00008921
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and mitotic cell cycle. Predicted to be part of replication fork protection complex. Predicted to be active in nuclear replication fork. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human WDHD1 (WD repeat and HMG-box DNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ctf-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (10961834..10965539, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Vacuolar protein-sorting-associated protein 36 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative elongation factor 1-gamma Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target. McLellan J, et al. Mol Biol Cell, 2009 Dec. PMID 19846659, Free PMC Article
    2. DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans. Xia Y, et al. Science, 2023 Sep 22. PMID 37590372, Free PMC Article
    3. CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Sonneville R, et al. Nat Cell Biol, 2017 May. PMID 28368371, Free PMC Article
    4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of replication fork protection complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Minichromosome loss protein Mcl1 middle region domain-containing protein
    NP_505799.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10961834..10965539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073398.5 → NP_505799.1  Minichromosome loss protein Mcl1 middle region domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19520
      Conserved Domains (3) summary
      sd00039
      Location:154 → 189
      7WD40; WD40 repeat [structural motif]
      pfam12341
      Location:442 → 764
      Mcl1_mid; Minichromosome loss protein, Mcl1, middle region
      cl29593
      Location:112 → 282
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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