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    cka-1 Choline/ethanolamine kinase [ Caenorhabditis elegans ]

    Gene ID: 177807, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cka-1
    Official Full Name
    Choline/ethanolamine kinase
    Primary source
    WormBase:WBGene00000509
    Locus tag
    CELE_C28D4.2
    See related
    AllianceGenome:WB:WBGene00000509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables choline kinase activity. Involved in CDP-choline pathway. Located in cell cortex. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKA (choline kinase alpha) and CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cka-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (9731737..9737621, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-100 Neighboring gene Ubiquitin-like domain-containing protein Neighboring gene glutamine synthetase Neighboring gene DUF1248 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery. Zhang L, et al. J Biol Chem, 2001 Mar 30. PMID 11134025
    2. A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3. Zhang L, et al. J Biol Chem, 2001 Mar 30. PMID 11134024
    3. Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization. Gee P, et al. Biochim Biophys Acta, 2003 May 30. PMID 12758145
    4. Protein kinase C isotypes in C. elegans. Tabuse Y. J Biochem, 2002 Oct. PMID 12359064
    5. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Wang C, et al. Nat Commun, 2022 Nov 10. PMID 36357390, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables choline kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ethanolamine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CDP-choline pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Choline/ethanolamine kinase
    NP_001129849.1
    • Confirmed by transcript evidence
    NP_001293883.1
    • Partially confirmed by transcript evidence
    NP_501732.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9731737..9737621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069331.4 → NP_501732.1  Choline/ethanolamine kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17610
      Conserved Domains (2) summary
      PLN02236
      Location:100 → 467
      PLN02236; choline kinase
      cd05156
      Location:112 → 465
      ChoK_euk; Euykaryotic Choline Kinase

    2. NM_001306954.3 → NP_001293883.1  Choline/ethanolamine kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AIW1
      Conserved Domains (2) summary
      PLN02236
      Location:74 → 444
      PLN02236; choline kinase
      cd05156
      Location:86 → 442
      ChoK_euk; Euykaryotic Choline Kinase

    3. NM_001136377.4 → NP_001129849.1  Choline/ethanolamine kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129849.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3GWD5
      Conserved Domains (2) summary
      PLN02236
      Location:74 → 441
      PLN02236; choline kinase
      cd05156
      Location:86 → 439
      ChoK_euk; Euykaryotic Choline Kinase
    Nucleotide Protein
    Heading Accession and Version

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