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    kvs-2 BTB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kvs-2
    Official Full Name
    BTB domain-containing protein
    Primary source
    WormBase:WBGene00007862
    Locus tag
    CELE_C32C4.1
    See related
    AllianceGenome:WB:WBGene00007862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in alcohol dependence; developmental and epileptic encephalopathy 26; epilepsy; and retinal cone dystrophy 3B. Orthologous to several human genes including KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kvs-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    16
    Sequence:
    Chromosome: V; NC_003283.11 (10636022..10645135)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DM domain-containing protein mab-23 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Recep_L_domain domain-containing protein Neighboring gene Transmembrane protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BTB domain-containing protein
    NP_001122871.1
    • Partially confirmed by transcript evidence
    NP_001256235.1
    • Confirmed by transcript evidence
    NP_001256236.1
    • Partially confirmed by transcript evidence
    NP_001256237.1
    • Partially confirmed by transcript evidence
    NP_001256238.1
    • Partially confirmed by transcript evidence
    NP_001256239.1
    • Confirmed by transcript evidence
    NP_001256240.1
    • Confirmed by transcript evidence
    NP_505725.3
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10636022..10645135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269306.3 → NP_001256235.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256235.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9N132
      Conserved Domains (2) summary
      cd18317
      Location:71 → 159
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:289 → 495
      Ion_trans; Ion transport protein

    2. NM_001269307.4 → NP_001256236.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256236.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      J3K003
      Conserved Domains (2) summary
      cd18317
      Location:111 → 199
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:329 → 535
      Ion_trans; Ion transport protein

    3. NM_001269308.3 → NP_001256237.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256237.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9N131
      Conserved Domains (2) summary
      cd18317
      Location:59 → 147
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:277 → 483
      Ion_trans; Ion transport protein

    4. NM_001269309.4 → NP_001256238.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2X0
      Conserved Domains (2) summary
      cd18317
      Location:51 → 139
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:269 → 475
      Ion_trans; Ion transport protein

    5. NM_073324.6 → NP_505725.3  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505725.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18351
      Conserved Domains (2) summary
      cd18317
      Location:65 → 153
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:283 → 489
      Ion_trans; Ion transport protein

    6. NM_001269310.2 → NP_001256239.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256239.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9N133
      Conserved Domains (2) summary
      cd18317
      Location:65 → 153
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:283 → 489
      Ion_trans; Ion transport protein

    7. NM_001129399.3 → NP_001122871.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122871.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7UQ08
      Conserved Domains (2) summary
      cd18317
      Location:65 → 153
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:283 → 498
      Ion_trans; Ion transport protein

    8. NM_001269311.3 → NP_001256240.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCS0
      Conserved Domains (2) summary
      cd18317
      Location:32 → 120
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:250 → 456
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version

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