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    nish-1 PX domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177981, updated on 27-Dec-2024

    Summary

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    Official Symbol
    nish-1
    Official Full Name
    PX domain-containing protein
    Primary source
    WormBase:WBGene00008750
    Locus tag
    CELE_F13E9.1
    See related
    AllianceGenome:WB:WBGene00008750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nish-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (10864331..10873635)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Histidine--tRNA ligase Neighboring gene Pre-mRNA-splicing factor RBM22 Neighboring gene Transmembrane protein Neighboring gene Neuropeptide-Like Protein Neighboring gene FIP (Fungus-Induced Protein) Related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1-imidazoline receptor. Bennett DF, et al. Aging Cell, 2023 Feb. PMID 36670049, Free PMC Article
    2. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
    3. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PX domain-containing protein
    NP_502016.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10864331..10873635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069615.6 → NP_502016.2  PX domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502016.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8F807
      Conserved Domains (3) summary
      COG4886
      Location:289 → 423
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:291 → 313
      LRR_RI; leucine-rich repeat [structural motif]
      cl02563
      Location:18 → 137
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein
    Heading Accession and Version

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