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    ceh-38 Homeobox protein ceh-38;One cut domain family member [ Caenorhabditis elegans ]

    Gene ID: 174136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceh-38
    Official Full Name
    Homeobox protein ceh-38;One cut domain family member
    Primary source
    WormBase:WBGene00000459
    Locus tag
    CELE_F22D3.1
    See related
    AllianceGenome:WB:WBGene00000459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including body wall musculature; digestive tract; hypodermis; neurons; and somatic nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceh-38 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (6951526..6955409)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Folliculin;Folliculin DENN domain-containing protein;UDENN FLCN/SMCR8-type domain-containing protein Neighboring gene ncRNA Neighboring gene Mucosa-associated lymphoid tissue lymphoma translocation protein 1 Neighboring gene Sex-determining transformer protein 2 Neighboring gene Translation initiation factor eIF2B subunit gamma Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid expression screening of Caenorhabditis elegans homeobox open reading frames using a two-step polymerase chain reaction promoter-gfp reporter construction technique. Cassata G, et al. Gene, 1998 May 28. PMID 9661672
    2. Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins. Lannoy VJ, et al. J Biol Chem, 1998 May 29. PMID 9593691
    3. Loss and gain of domains during evolution of cut superclass homeobox genes. Bürglin TR, et al. Int J Dev Biol, 2002 Jan. PMID 11902672
    4. A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions. Fuxman Bass JI, et al. Mol Syst Biol, 2016 Oct 24. PMID 27777270, Free PMC Article
    5. MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans. Vérièpe-Salerno J, et al. Autophagy Rep, 2023 Nov 9. PMID 38510643, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox protein ceh-38;One cut domain family member
    NP_001338814.1
    • Confirmed by transcript evidence
    NP_001338820.1
    • Confirmed by transcript evidence
    NP_001338821.1
    • Confirmed by transcript evidence
    NP_001367332.1
    • Confirmed by transcript evidence
    NP_001368648.1
    • Confirmed by transcript evidence
    NP_001368649.1
    • Confirmed by transcript evidence
    NP_001368650.1
    • Confirmed by transcript evidence
    NP_001368651.1
    • Confirmed by transcript evidence
    NP_001368652.1
    • Confirmed by transcript evidence
    NP_001368653.1
    • Confirmed by transcript evidence
    NP_001368654.1
    • Confirmed by transcript evidence
    NP_001368655.1
    • Confirmed by transcript evidence
    NP_001368656.1
    • Confirmed by transcript evidence
    NP_001368657.1
    • Confirmed by transcript evidence
    NP_001370972.1
    • Confirmed by transcript evidence
    NP_741018.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6951526..6955409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001351914.2 → NP_001338821.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBM0
      Conserved Domains (2) summary
      smart00389
      Location:429 → 485
      HOX; Homeodomain
      pfam02376
      Location:313 → 389
      CUT; CUT domain

    2. NM_001381475.2 → NP_001368651.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RC50
      Conserved Domains (2) summary
      smart00389
      Location:421 → 477
      HOX; Homeodomain
      pfam02376
      Location:307 → 384
      CUT; CUT domain

    3. NM_001381472.2 → NP_001368657.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBK4
      Conserved Domains (2) summary
      smart00389
      Location:430 → 486
      HOX; Homeodomain
      pfam02376
      Location:316 → 393
      CUT; CUT domain

    4. NM_171852.2 → NP_741018.1  Homeobox protein ceh-38 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741018.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19720
      Conserved Domains (2) summary
      smart00389
      Location:418 → 474
      HOX; Homeodomain
      pfam02376
      Location:304 → 380
      CUT; CUT domain

    5. NM_001381471.2 → NP_001368648.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBJ2
      Conserved Domains (2) summary
      smart00389
      Location:430 → 486
      HOX; Homeodomain
      pfam02376
      Location:316 → 393
      CUT; CUT domain

    6. NM_001381477.2 → NP_001367332.1  Homeobox protein ceh-38 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19720, Q95QJ5
      Conserved Domains (2) summary
      smart00389
      Location:427 → 483
      HOX; Homeodomain
      pfam02376
      Location:313 → 390
      CUT; CUT domain

    7. NM_001381476.1 → NP_001368652.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBR4
      Conserved Domains (2) summary
      smart00389
      Location:421 → 477
      HOX; Homeodomain
      pfam02376
      Location:307 → 384
      CUT; CUT domain

    8. NM_001351913.3 → NP_001338820.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBK3
      Conserved Domains (2) summary
      smart00389
      Location:429 → 485
      HOX; Homeodomain
      pfam02376
      Location:313 → 389
      CUT; CUT domain

    9. NM_001381478.2 → NP_001368653.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBS0
      Conserved Domains (2) summary
      smart00389
      Location:427 → 483
      HOX; Homeodomain
      pfam02376
      Location:313 → 390
      CUT; CUT domain

    10. NM_001381480.1 → NP_001368655.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RCV1
      Conserved Domains (2) summary
      smart00389
      Location:420 → 476
      HOX; Homeodomain
      pfam02376
      Location:304 → 381
      CUT; CUT domain

    11. NM_001381479.1 → NP_001368654.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBN7
      Conserved Domains (2) summary
      smart00389
      Location:420 → 476
      HOX; Homeodomain
      pfam02376
      Location:304 → 381
      CUT; CUT domain

    12. NM_001381473.2 → NP_001368649.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBJ5
      Conserved Domains (2) summary
      smart00389
      Location:423 → 479
      HOX; Homeodomain
      pfam02376
      Location:307 → 384
      CUT; CUT domain

    13. NM_001351905.5 → NP_001338814.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RCT5
      Conserved Domains (2) summary
      smart00389
      Location:432 → 488
      HOX; Homeodomain
      pfam02376
      Location:316 → 392
      CUT; CUT domain

    14. NM_001383875.2 → NP_001370972.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBM7
      Conserved Domains (2) summary
      smart00389
      Location:432 → 488
      HOX; Homeodomain
      pfam02376
      Location:316 → 393
      CUT; CUT domain

    15. NM_001381481.1 → NP_001368656.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBK2
      Conserved Domains (2) summary
      smart00389
      Location:418 → 474
      HOX; Homeodomain
      pfam02376
      Location:304 → 381
      CUT; CUT domain

    16. NM_001381474.1 → NP_001368650.1  One cut domain family member [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RC48
      Conserved Domains (2) summary
      smart00389
      Location:423 → 479
      HOX; Homeodomain
      pfam02376
      Location:307 → 384
      CUT; CUT domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19720.2

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