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    aagr-3 Glucosidase II subunit alpha [ Caenorhabditis elegans ]

    Gene ID: 179364, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aagr-3
    Official Full Name
    Glucosidase II subunit alpha
    Primary source
    WormBase:WBGene00009583
    Locus tag
    CELE_F40F9.6
    See related
    AllianceGenome:WB:WBGene00009583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables alpha-1,4-glucosidase activity. Involved in glycogen catabolic process. Predicted to be located in lysosome. Is expressed in anal depressor muscle; intestine; nervous system; pharynx; and rectal epithelium. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to human GANAB (glucosidase II alpha subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aagr-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (9725984..9729512, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Proton-coupled folate transporter Neighboring gene Transcription factor CBF/NF-Y/archaeal histone domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bioinformatic and biochemical studies point to AAGR-1 as the ortholog of human acid alpha-glucosidase in Caenorhabditis elegans. Sikora J, et al. Mol Cell Biochem, 2010 Aug. PMID 20349118
    2. A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis. Couillault C, et al. Virulence, 2012 May 1. PMID 22546897, Free PMC Article
    3. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Glucosidase II subunit alpha
    NP_001263844.1
    • Confirmed by transcript evidence
    NP_505507.1
    • Confirmed by transcript evidence
    NP_505508.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9725984..9729512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073106.2 → NP_505507.1  Glucosidase II subunit alpha [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505507.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20239
      Conserved Domains (3) summary
      cd06603
      Location:358 → 827
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:229 → 358
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam17137
      Location:803 → 875
      DUF5110; Domain of unknown function (DUF5110)

    2. NM_073107.8 → NP_505508.1  Glucosidase II subunit alpha [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3F8
      Conserved Domains (3) summary
      cd06603
      Location:344 → 813
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:215 → 344
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam17137
      Location:789 → 861
      DUF5110; Domain of unknown function (DUF5110)

    3. NM_001276915.3 → NP_001263844.1  Glucosidase II subunit alpha [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      J7SA48
      Conserved Domains (2) summary
      cd06603
      Location:93 → 562
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:1 → 93
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    Nucleotide Protein
    Heading Accession and Version

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