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    zmp-4 Hemopexin;Peptidase metallopeptidase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179991, updated on 9-Dec-2024

    Summary

    Official Symbol
    zmp-4
    Official Full Name
    Hemopexin;Peptidase metallopeptidase domain-containing protein
    Primary source
    WormBase:WBGene00012364
    Locus tag
    CELE_W09D12.1
    See related
    AllianceGenome:WB:WBGene00012364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to be located in extracellular matrix. Is expressed in body wall musculature. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human MMP2 (matrix metallopeptidase 2); MMP23B (matrix metallopeptidase 23B); and MMP9 (matrix metallopeptidase 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See zmp-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    13
    Sequence:
    Chromosome: V; NC_003283.11 (14917735..14921609, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene EGF domain-specific O-linked N-acetylglucosamine transferase;Heparan N-sulfatase Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein Neighboring gene Serpentine receptor class gamma Neighboring gene Serpentine receptor class gamma

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Hemopexin;Peptidase metallopeptidase domain-containing protein
    NP_001355447.1
    • Confirmed by transcript evidence
    NP_506678.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14917735..14921609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074277.7NP_506678.2  Peptidase metallopeptidase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506678.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23227
      Conserved Domains (2) summary
      cd00094
      Location:283471
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:118268
      Peptidase_M10; Matrixin
    2. NM_001368476.2NP_001355447.1  Hemopexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1E3U1
      Conserved Domains (1) summary
      cd00094
      Location:56244
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...