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    nhx-4 Sodium/hydrogen exchanger [ Caenorhabditis elegans ]

    Gene ID: 180964, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhx-4
    Official Full Name
    Sodium/hydrogen exchanger
    Primary source
    WormBase:WBGene00003732
    Locus tag
    CELE_F14B8.1
    See related
    AllianceGenome:WB:WBGene00003732
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed widely. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhx-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (6914289..6921136)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Systemic RNA interference defective protein 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Otopetrin-2 Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein;Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NHX family of Na+-H+ exchangers in Caenorhabditis elegans. Nehrke K, et al. J Biol Chem, 2002 Aug 9. PMID 12021279
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sodium/hydrogen exchanger
    NP_001024562.1
    • Confirmed by transcript evidence
    NP_001367515.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6914289..6921136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029391.5 → NP_001024562.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024562.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDU2
      Conserved Domains (2) summary
      TIGR00840
      Location:94 → 637
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:104 → 508
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    2. NM_001381015.2 → NP_001367515.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECB7
      Conserved Domains (1) summary
      TIGR00840
      Location:29 → 572
      b_cpa1; sodium/hydrogen exchanger 3
    Nucleotide Protein
    Heading Accession and Version

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