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    mans-4 alpha-1,2-Mannosidase [ Caenorhabditis elegans ]

    Gene ID: 177726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mans-4
    Official Full Name
    alpha-1,2-Mannosidase
    Primary source
    WormBase:WBGene00013881
    Locus tag
    CELE_ZC410.3
    See related
    AllianceGenome:WB:WBGene00013881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in ERAD pathway. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in Rafiq syndrome. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mans-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (9076501..9078569, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-11 Neighboring gene Mitochondrial-processing peptidase subunit beta Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    2. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    3. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,2-Mannosidase
    NP_001255361.1
    • Confirmed by transcript evidence
    NP_001255362.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9076501..9078569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268432.3 → NP_001255361.1  alpha-1,2-Mannosidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255361.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23296
      Conserved Domains (1) summary
      pfam01532
      Location:89 → 530
      Glyco_hydro_47; Glycosyl hydrolase family 47

    2. NM_001268433.3 → NP_001255362.1  alpha-1,2-Mannosidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT22
      Conserved Domains (1) summary
      pfam01532
      Location:71 → 512
      Glyco_hydro_47; Glycosyl hydrolase family 47
    Nucleotide Protein
    Heading Accession and Version

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