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    pycr-4 Putative pyrroline-5-carboxylate reductase 4 [ Caenorhabditis elegans ]

    Gene ID: 177519, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pycr-4
    Official Full Name
    Putative pyrroline-5-carboxylate reductase 4
    Primary source
    WormBase:WBGene00018904
    Locus tag
    CELE_F55G1.9
    See related
    AllianceGenome:WB:WBGene00018904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Is expressed in hypodermis and intestinal cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pycr-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (7476163..7477297, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase plk-3 Neighboring gene RING-CH-type domain-containing protein Neighboring gene SLC (SoLute Carrier) homolog Neighboring gene Kinetochore-associated protein rod-1 Neighboring gene Histone H2A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. Chen Y, et al. BMC Biotechnol, 2007 Jul 30. PMID 17663785, Free PMC Article
    2. PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability. Cordeiro Rodrigues RJ, et al. Genes Dev, 2019 Jul 1. PMID 31147388, Free PMC Article
    3. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative pyrroline-5-carboxylate reductase 4
    NP_501199.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7476163..7477297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068798.6 → NP_501199.1  Putative pyrroline-5-carboxylate reductase 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501199.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20848
      Conserved Domains (3) summary
      PRK11880
      Location:18 → 296
      PRK11880; pyrroline-5-carboxylate reductase; Reviewed
      pfam03807
      Location:19 → 112
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
      pfam14748
      Location:181 → 292
      P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20848.1

    Gene LinkOut

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