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    cbp-1 Protein cbp-1 [ Caenorhabditis elegans ]

    Gene ID: 176380, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cbp-1
    Official Full Name
    Protein cbp-1
    Primary source
    WormBase:WBGene00000366
    Locus tag
    CELE_R10E11.1
    See related
    AllianceGenome:WB:WBGene00000366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; histone acetyltransferase activity; and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of distal tip cell migration; and spermatogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; body wall musculature; distal tip cell; nervous system; and tail. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; acute myeloid leukemia; colorectal cancer; and congestive heart failure. Orthologous to several human genes including CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cbp-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (9766510..9774825)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene GRIP and coiled-coil domain-containing protein 2 Neighboring gene Regulator of microtubule dynamics protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquitin carboxyl-terminal hydrolase 46 Neighboring gene Xylosylprotein 4-beta-galactosyltransferase Neighboring gene V-type proton ATPase 16 kDa proteolipid subunit c 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone acetylation promotes long-lasting defense responses and longevity following early life heat stress. Zhou L, et al. PLoS Genet, 2019 Apr. PMID 31034475, Free PMC Article
    2. FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. Lublin A, et al. PLoS One, 2011. PMID 22114686, Free PMC Article
    3. Cannabidiol regulates CB1-pSTAT3 signaling for neurite outgrowth, prolongs lifespan, and improves health span in Caenorhabditis elegans of Aβ pathology models. Wang Z, et al. FASEB J, 2021 May. PMID 33817834
    4. Neuronal CBP-1 is Required for Enhanced Body Muscle Proteostasis in Response to Reduced Translation Downstream of mTOR. Snow S, et al. Front Biosci (Landmark Ed), 2024 Jul 23. PMID 39082355, Free PMC Article
    5. CBP-1 Acts in GABAergic Neurons to Double Life Span in Axenically Cultured Caenorhabditis elegans. Cai H, et al. J Gerontol A Biol Sci Med Sci, 2019 Jul 12. PMID 29099917, Free PMC Article

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuronal CBP-1 is Required for Enhanced Body Muscle Proteostasis in Response to Reduced Translation Downstream of mTOR.
      Title: Neuronal CBP-1 is Required for Enhanced Body Muscle Proteostasis in Response to Reduced Translation Downstream of mTOR.
    2. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.
      Title: The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.
    3. SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol.
      Title: SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol.
    4. cbp-1 is induced by bacterial dilution dietary restriction (bDR)
      Title: Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling.
    5. CRE-mediated transcription in a subset of head neurons in living nematodes is regulated by the CaMK cascade
      Title: A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-lysine-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of distal tip cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein cbp-1
    NP_001122711.2
    • Confirmed by transcript evidence
    NP_499160.2
    • Confirmed by transcript evidence
    NP_499161.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9766510..9774825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066759.5 → NP_499160.2  Protein cbp-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499160.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B0M0M3, P34545
      Conserved Domains (8) summary
      cd05495
      Location:866 → 972
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:1551 → 1629
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:1497 → 1535
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:984 → 1067
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:1069 → 1100
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02172
      Location:593 → 673
      KIX; KIX domain
      pfam06001
      Location:970 → 1009
      DUF902; Domain of Unknown Function (DUF902)
      cl02120
      Location:1131 → 1427
      HAT_KAT11; Histone acetylation protein

    2. NM_001129239.3 → NP_001122711.2  Protein cbp-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122711.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34545
      Conserved Domains (9) summary
      cd05495
      Location:855 → 961
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:1540 → 1618
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:1486 → 1524
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:973 → 1056
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:1058 → 1089
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02135
      Location:415 → 491
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:582 → 662
      KIX; KIX domain
      pfam06001
      Location:959 → 998
      DUF902; Domain of Unknown Function (DUF902)
      cl02120
      Location:1120 → 1416
      HAT_KAT11; Histone acetylation protein

    3. NM_066760.8 → NP_499161.2  Protein cbp-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499161.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34545
      Conserved Domains (9) summary
      cd05495
      Location:855 → 961
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:1540 → 1618
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:1486 → 1524
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:973 → 1056
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:1058 → 1089
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02135
      Location:415 → 491
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:582 → 662
      KIX; KIX domain
      pfam06001
      Location:959 → 998
      DUF902; Domain of Unknown Function (DUF902)
      cl02120
      Location:1120 → 1416
      HAT_KAT11; Histone acetylation protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34545.6

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