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    hrpa-1 Heterogeneous nuclear ribonucleoprotein A1 [ Caenorhabditis elegans ]

    Gene ID: 177101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hrpa-1
    Official Full Name
    Heterogeneous nuclear ribonucleoprotein A1
    Primary source
    WormBase:WBGene00001999
    Locus tag
    CELE_F42A6.7
    See related
    AllianceGenome:WB:WBGene00001999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Involved in hemidesmosome assembly. Located in chromosome, telomeric region. Is expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; distal myopathy 3; inclusion body myopathy with Paget disease of bone and frontotemporal dementia (multiple); and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) and HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hrpa-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (3336920..3338863, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Hikeshi-like N-terminal domain-containing protein;Hikeshi-like domain-containing protein Neighboring gene pseudo Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress. Ryan VH, et al. MicroPubl Biol, 2021 Feb 3. PMID 33554054, Free PMC Article
    2. Long lifespan in worms with long telomeric DNA. Joeng KS, et al. Nat Genet, 2004 Jun. PMID 15122256
    3. Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration. Ryan VH, et al. EMBO J, 2021 Feb 1. PMID 33349959, Free PMC Article
    4. Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Longman D, et al. Genes Dev, 2007 May 1. PMID 17437990, Free PMC Article
    5. CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development. Zahreddine H, et al. Curr Biol, 2010 Feb 23. PMID 20153198

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hemidesmosome assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Heterogeneous nuclear ribonucleoprotein A1
    NP_001040945.1
    • Confirmed by transcript evidence
    NP_001367846.1
    • Partially confirmed by transcript evidence
    NP_001370723.1
    • Confirmed by transcript evidence
    NP_001379954.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3336920..3338863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380140.2 → NP_001367846.1  Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd12328
      Location:77 → 149
      RRM2_hnRNPA_like; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:1 → 63
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001392280.1 → NP_001379954.1  Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd12328
      Location:77 → 149
      RRM2_hnRNPA_like; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:1 → 63
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001383064.2 → NP_001370723.1  Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22037, Q336L3, Q336L4, Q95X69
      Conserved Domains (2) summary
      cd12328
      Location:115 → 187
      RRM2_hnRNPA_like; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:24 → 101
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001047480.6 → NP_001040945.1  Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22037
      Conserved Domains (2) summary
      cd12328
      Location:115 → 187
      RRM2_hnRNPA_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A subfamily
      cd12578
      Location:24 → 101
      RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22037.1

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