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    alh-11 4-trimethylaminobutyraldehyde dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 185679, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alh-11
    Official Full Name
    4-trimethylaminobutyraldehyde dehydrogenase
    Primary source
    WormBase:WBGene00000117
    Locus tag
    CELE_F42G9.5
    See related
    AllianceGenome:WB:WBGene00000117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 4-trimethylammoniobutyraldehyde dehydrogenase activity and aminobutyraldehyde dehydrogenase (NAD+) activity. Is expressed in neurons. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See alh-11 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (774321..778154, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Microtubule-associated protein Neighboring gene Putative protein-tyrosine sulfotransferase Neighboring gene Peptidyl-prolyl cis-trans isomerase 6 Neighboring gene sn-1-specific diacylglycerol lipase Neighboring gene Protein phosphatase ppm-1.G Neighboring gene Synaptotagmin 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states. Hardege I, et al. Proc Natl Acad Sci U S A, 2022 Nov 29. PMID 36413500, Free PMC Article
    2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    3. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminobutyraldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    4-trimethylaminobutyraldehyde dehydrogenase
    NP_001379574.1
    • Confirmed by transcript evidence
    NP_001379575.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      774321..778154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393264.1 → NP_001379574.1  4-trimethylaminobutyraldehyde dehydrogenase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20352
      Conserved Domains (2) summary
      cd07090
      Location:225 → 681
      ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1
      cl21534
      Location:30 → 131
      NLPC_P60; NlpC/P60 family

    2. NM_001393265.1 → NP_001379575.1  4-trimethylaminobutyraldehyde dehydrogenase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MNS6
      Conserved Domains (1) summary
      cd07090
      Location:41 → 497
      ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1
    Nucleotide Protein
    Heading Accession and Version

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