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    top-3A DNA topoisomerase 3 [ Caenorhabditis elegans ]

    Gene ID: 176631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    top-3A
    Official Full Name
    DNA topoisomerase 3
    Primary source
    WormBase:WBGene00006596
    Locus tag
    CELE_Y56A3A.27
    See related
    AllianceGenome:WB:WBGene00006596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Involved in DNA topological change. Located in nucleus. Is expressed in gonad. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Orthologous to human TOP3A (DNA topoisomerase III alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See top-3A in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (11949918..11960180, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Homeobox protein cut-like Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene Uracil-DNA glycosylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of Caenorhabditis elegans DNA topoisomerase IIIalpha. Kim YC, et al. Nucleic Acids Res, 2000 May 1. PMID 10756204, Free PMC Article
    2. Coaction of DNA topoisomerase IIIalpha and a RecQ homologue during the germ-line mitosis in Caenorhabditis elegans. Kim YC, et al. Genes Cells, 2002 Jan. PMID 11856370
    3. Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex. Velkova M, et al. PLoS Genet, 2021 Jul. PMID 34252074, Free PMC Article
    4. Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance. Jagut M, et al. PLoS Biol, 2016 Mar. PMID 27011106, Free PMC Article
    5. Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line. Wicky C, et al. Mol Cell Biol, 2004 Jun. PMID 15143192, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline.
      Title: The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline.
    2. Needed to maintain low levels of double-strand breaks in normally proliferating germ cells.
      Title: Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    DNA topoisomerase 3
    NP_499558.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11949918..11960180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067157.7 → NP_499558.1  DNA topoisomerase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499558.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61660, Q9U223
      Conserved Domains (4) summary
      cd03362
      Location:5 → 161
      TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...
      COG0550
      Location:5 → 597
      TopA; DNA topoisomerase IA [Replication, recombination and repair]
      cd00186
      Location:166 → 590
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
      pfam06839
      Location:717 → 759
      zf-GRF; GRF zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61660.1

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