cul-6 Cullin-6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cul-6
Official Full Name: Cullin-6
Primary source: WormBase:WBGene00000841
Locus tag: CELE_K08E7.7
See related: AllianceGenome:WB:WBGene00000841
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Involved in defense response to virus. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in intestine and pharynx. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cul-6 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (12586485..12590451, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CUL-6/cullin ubiquitin ligase-mediated degradation of HSP-90 by intestinal lysosomes promotes thermotolerance.
Title: CUL-6/cullin ubiquitin ligase-mediated degradation of HSP-90 by intestinal lysosomes promotes thermotolerance.
Punctuated Loci on Chromosome IV Determine Natural Variation in Orsay Virus Susceptibility of Caenorhabditis elegans Strains Bristol N2 and Hawaiian CB4856.
Title: Punctuated Loci on Chromosome IV Determine Natural Variation in Orsay Virus Susceptibility of Caenorhabditis elegans Strains Bristol N2 and Hawaiian CB4856.
Study used coimmunoprecipitation studies paired with genetic analysis to define the cullin-RING ligase components that act together with CUL-6 to promote thermotolerance in C. elegans and identified three core components and two F-box adaptors of a cullin-RING ligase as part of the intracellular pathogen response in C. elegans, which adds to understanding of how organisms cope with proteotoxic stress.
Title: A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K08E7.7 (e-PCR)
- UniSTS:307788

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cullin-6

NP_502412.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

12586485..12590451 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070011.5 → NP_502412.1 Cullin-6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502412.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21346

Conserved Domains (3) summary

smart00182
Location:411 → 547

CULLIN; Cullin

smart00884
Location:656 → 723

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:10 → 596

Cullin; Cullin family