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    set-32 SET domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183391, updated on 9-Dec-2024

    Summary

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    Official Symbol
    set-32
    Official Full Name
    SET domain-containing protein
    Primary source
    WormBase:WBGene00008062
    Locus tag
    CELE_C41G7.4
    See related
    AllianceGenome:WB:WBGene00008062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone H3 methyltransferase activity. Predicted to be located in chromatin. Is expressed in germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See set-32 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (9519244..9521275)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Messenger RNA-binding inhibitor of apoptosis 1 Neighboring gene ncRNA Neighboring gene Aryl hydrocarbon receptor protein 1 Neighboring gene ncRNA Neighboring gene Lipoprotein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3. Schwartz-Orbach L, et al. Elife, 2020 Aug 17. PMID 32804637, Free PMC Article
    2. Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance. Woodhouse RM, et al. Cell Rep, 2018 Nov 20. PMID 30463020
    3. H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes. Lev I, et al. Elife, 2019 Mar 14. PMID 30869075, Free PMC Article
    4. The spatial and temporal dynamics of nuclear RNAi-targeted retrotransposon transcripts in Caenorhabditis elegans. Ni JZ, et al. Development, 2018 Oct 22. PMID 30254142, Free PMC Article
    5. Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans. Kalinava N, et al. Epigenetics Chromatin, 2017. PMID 28228846, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3.
      Title: Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3.
    2. silencing establishment at the endogenous targets of germline nuclear RNAi also requires SET-32.
      Title: C. elegans Heterochromatin Factor SET-32 Plays an Essential Role in Transgenerational Establishment of Nuclear RNAi-Mediated Epigenetic Silencing.
    3. the putative histone methyltransferases SET-25 and SET-32 are required for establishment of a transgenerational silencing signal but not for long-term maintenance of this signal between subsequent generations
      Title: Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone H3 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SET domain-containing protein
    NP_492529.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9519244..9521275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060128.3 → NP_492529.2  SET domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492529.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93368
      Conserved Domains (1) summary
      smart00317
      Location:307 → 455
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    Nucleotide Protein
    Heading Accession and Version

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