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    dnbp-1 SH3 domain-containing GRB2-like protein;SH3 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 4926960, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnbp-1
    Official Full Name
    SH3 domain-containing GRB2-like protein;SH3 domain-containing protein
    Primary source
    WormBase:WBGene00044989
    Locus tag
    CELE_Y37A1B.17
    See related
    AllianceGenome:WB:WBGene00044989
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in cataract 48. Orthologous to several human genes including DNMBP (dynamin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dnbp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    20
    Sequence:
    Chromosome: IV; NC_003282.8 (13964356..13979847, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene FAM65 N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GEX Interacting protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    2. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing GRB2-like protein;SH3 domain-containing protein
    NP_001076722.2
    • Confirmed by transcript evidence
    NP_001255773.1
    • Confirmed by transcript evidence
    NP_001255774.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13964356..13979847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083253.6 → NP_001076722.2  SH3 domain-containing GRB2-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076722.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECK4
      Conserved Domains (5) summary
      smart00326
      Location:169 → 224
      SH3; Src homology 3 domains
      cl02571
      Location:468 → 645
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl12013
      Location:643 → 870
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:1470 → 1522
      SH3; Src Homology 3 domain superfamily
      cl23807
      Location:1387 → 1444
      WWbp; WW-domain ligand protein

    2. NM_001268844.3 → NP_001255773.1  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE73
      Conserved Domains (5) summary
      smart00326
      Location:32 → 87
      SH3; Src homology 3 domains
      cl02571
      Location:331 → 508
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl12013
      Location:506 → 733
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:1333 → 1385
      SH3; Src Homology 3 domain superfamily
      cl23807
      Location:1250 → 1307
      WWbp; WW-domain ligand protein

    3. NM_001268845.3 → NP_001255774.1  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255774.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEQ7
      Conserved Domains (1) summary
      cl17036
      Location:553 → 605
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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