unc-116 Kinesin heavy chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-116
Official Full Name: Kinesin heavy chain
Primary source: WormBase:WBGene00006840
Locus tag: CELE_R05D3.7
See related: AllianceGenome:WB:WBGene00006840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables plus-end-directed microtubule motor activity. Involved in several processes, including microtubule cytoskeleton organization; organelle transport along microtubule; and positive regulation of cell projection organization. Located in several cellular components, including neuron projection; nuclear envelope; and synapse. Part of kinesin I complex. Is expressed in several structures, including intestine; nervous system; pharynx; rectal epithelium; and tail. Human ortholog(s) of this gene implicated in several diseases, including amyotrophic lateral sclerosis type 25; autoimmune disease (multiple); complex cortical dysplasia with other brain malformations 2; hereditary spastic paraplegia 10; and prostate cancer. Orthologous to human KIF5A (kinesin family member 5A); KIF5B (kinesin family member 5B); and KIF5C (kinesin family member 5C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-116 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (8351164..8355174, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polarized localization of kinesin-1 and RIC-7 drives axonal mitochondria anterograde transport.
Title: Polarized localization of kinesin-1 and RIC-7 drives axonal mitochondria anterograde transport.
UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting.
Title: UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting.
CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.
Title: CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.
dendritic branch distribution depends on the balance between the molecular motors UNC-116 and dynein, and we propose that RAB-10 regulates dendrite morphology by balancing the activity of these motors to the transmembrane receptor DMA-1.
Title: RAB-10 Regulates Dendritic Branching by Balancing Dendritic Transport.
Kinesin-1 regulates dendrite microtubule polarity through directly gliding the plus-end-out MTs out of the dendrite using both the motor domain and the C-terminal MT-binding domain.
Title: Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans.
data support a model in which ongoing motor-driven delivery and removal of AMPARs controls not only the number but also the composition of synaptic AMPARs, and thus the strength of synaptic transmission.
Title: Kinesin-1 regulates synaptic strength by mediating the delivery, removal, and redistribution of AMPA receptors.
results support a model in which the MIG-15 kinase and the UNC-116-WVE-1 complex act on opposite sides of the growth cone to promote robust directional migration
Title: MIG-15 and ERM-1 promote growth cone directional migration in parallel to UNC-116 and WVE-1.
Data present evidence that bicd-1 operates in a conserved pathway with dhc-1 and unc-116.
Title: C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites.
Data support a model in which UNC-83 plays a central role in nuclear migration by acting to bridge the nuclear envelope and as a kinesin-1/Unc-116 cargo-specific adaptor so that motor-generated forces specifically move the nucleus as a single unit.
Title: UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R05D3.7 (e-PCR)
- UniSTS:312050

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal transport of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of meiotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of meiotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear migration along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polar body extrusion after meiotic divisions	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
part_of kinesin I complex	IPI Inferred from Physical Interaction more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Kinesin heavy chain

NP_001370811.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8351164..8355174 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001382938.2 → NP_001370811.1 Kinesin heavy chain [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P34540

Conserved Domains (2) summary

TIGR02169
Location:440 → 782

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

cd01369
Location:9 → 329

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup