rnf-113 putative E3 ubiquitin-protein ligase rnf113 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rnf-113
Official Full Name: putative E3 ubiquitin-protein ligase rnf113
Primary source: WormBase:WBGene00010476
Locus tag: CELE_K01G5.1
See related: AllianceGenome:WB:WBGene00010476
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination. Located in nucleus. Is expressed in head neurons; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 5. Orthologous to several human genes including RNF113A (ring finger protein 113A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rnf-113 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (10755624..10757640, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results lead us to suggest that RNF-113 and RFS-1 interact to promote the displacement of RPA-1 by RAD-51 on single-stranded DNA derived from ICLs.
Title: C. elegans ring finger protein RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K01G5.1 (e-PCR)
- UniSTS:306033

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in snoRNA splicing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of U2-type spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: putative E3 ubiquitin-protein ligase rnf113

NP_499375.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10755624..10757640 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066974.7 → NP_499375.1 putative E3 ubiquitin-protein ligase rnf113 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499375.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17917

Conserved Domains (2) summary

cd00162
Location:240 → 282

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00642
Location:180 → 202

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)