nhr-2 Nuclear hormone receptor family member nhr-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-2
Official Full Name: Nuclear hormone receptor family member nhr-2
Primary source: WormBase:WBGene00003601
Locus tag: CELE_C32F10.6
See related: AllianceGenome:WB:WBGene00003601
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; hormone-mediated signaling pathway; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including Cpaaaa; Cpaaap; Cpaapa; Cpaapp; and germ line. Human ortholog(s) of this gene implicated in Alzheimer's disease; carcinoma (multiple); congenital nongoitrous hypothyroidism 6; coronary artery disease (multiple); and lipid metabolism disorder. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha) and THRA (thyroid hormone receptor alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nhr-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (5818474..5821134, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C32F10.7 (e-PCR)
- UniSTS:315662

C32F10.6 (e-PCR)
- UniSTS:308689

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear hormone receptor family member nhr-2

NP_491689.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5818474..5821134 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059288.9 → NP_491689.4 Nuclear hormone receptor family member nhr-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491689.4

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10902

UniProtKB/TrEMBL

Q9BJL4

Conserved Domains (1) summary

cd06916
Location:218 → 296

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers