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    stn-1 Syntrophin-1 [ Caenorhabditis elegans ]

    Gene ID: 266844, updated on 9-Dec-2024

    Summary

    Official Symbol
    stn-1
    Official Full Name
    Syntrophin-1
    Primary source
    WormBase:WBGene00006062
    Locus tag
    CELE_F30A10.8
    See related
    AllianceGenome:WB:WBGene00006062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables acetylcholine transmembrane transporter activity and calcium channel regulator activity. Involved in several processes, including acetylcholine transport; muscle cell cellular homeostasis; and sarcomere organization. Part of dystrophin-associated glycoprotein complex. Is expressed in body wall musculature; enteric muscle; nervous system; and reproductive system. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 12; and sudden infant death syndrome. Orthologous to several human genes including SNTB2 (syntrophin beta 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See stn-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (9501268..9505173)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-3-phosphatase Neighboring gene Kinase Neighboring gene ncRNA Neighboring gene PIN domain-containing protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase usp-48 Neighboring gene miscRNA Neighboring gene Tudor domain-containing protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acetylcholine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calcium channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of dystrophin-associated glycoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of dystrophin-associated glycoprotein complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of dystrophin-associated glycoprotein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Syntrophin-1
    NP_492521.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9501268..9505173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060120.7NP_492521.1  Syntrophin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492521.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93646, Q9XVP8
      Conserved Domains (4) summary
      smart00233
      Location:228334
      PH; Pleckstrin homology domain
      cd00992
      Location:44125
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00169
      Location:228334
      PH; PH domain
      cl17171
      Location:152208
      PH-like; Pleckstrin homology-like domain