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    dhs-19 DeHydrogenases, Short chain [ Caenorhabditis elegans ]

    Gene ID: 179578, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhs-19
    Official Full Name
    DeHydrogenases, Short chain
    Primary source
    WormBase:WBGene00000982
    Locus tag
    CELE_T11F9.11
    See related
    AllianceGenome:WB:WBGene00000982
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be located in membrane. Predicted to be active in lipid droplet. Is expressed in body wall musculature; hypodermis; intestine; and pharynx. Orthologous to human SDR16C5 (short chain dehydrogenase/reductase family 16C member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhs-19 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (11489050..11490328, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene CX domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hydroxysteroid dehydrogenase family proteins on lipid droplets through bacteria, C. elegans, and mammals. Liu Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Aug. PMID 29702244
    2. Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism. Diot C, et al. Nat Commun, 2022 Sep 23. PMID 36151093, Free PMC Article
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DeHydrogenases, Short chain
    NP_505915.1
    • Product from WormBase gene class dhs;
      Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11489050..11490328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073514.8 → NP_505915.1  DeHydrogenases, Short chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505915.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22392
      Conserved Domains (2) summary
      cd05339
      Location:42 → 282
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      pfam00106
      Location:40 → 237
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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