zag-1 Zinc finger E-box-binding homeobox protein zag-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: zag-1
Official Full Name: Zinc finger E-box-binding homeobox protein zag-1
Primary source: WormBase:WBGene00006970
Locus tag: CELE_F28F9.1
See related: AllianceGenome:WB:WBGene00006970
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; neuron differentiation; and positive regulation of axon extension. Located in nucleus. Is expressed in several structures, including enteric muscle; intestine; neurons; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; Hirschsprung's disease; Mowat-Wilson syndrome; and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1) and ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See zag-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (3855843..3861569)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that zag-1 acts as transcriptional repressor controlling important aspects of terminal differentiation of neurons.
Title: zag-1, a Zn-finger homeodomain transcription factor controlling neuronal differentiation and axon outgrowth in C. elegans.
Data suggest that ZAG-1 acts as a transcriptional repressor to regulate multiple, discrete, neuron-specific aspects of terminal differentiation, including cell migration, axonal development and gene expression.
Title: C. elegans ZAG-1, a Zn-finger-homeodomain protein, regulates axonal development and neuronal differentiation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F28F9.1 (e-PCR)
- UniSTS:310012

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Zinc finger E-box-binding homeobox protein zag-1

NP_500424.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

3855843..3861569

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068023.7 → NP_500424.3 Zinc finger E-box-binding homeobox protein zag-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500424.3

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EBU4

Conserved Domains (5) summary

COG5048
Location:506 → 559

COG5048; FOG: Zn-finger [General function prediction only]

cd00086
Location:225 → 282

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00017
Location:483 → 503

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:24 → 46

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:38 → 61

zf-H2C2_2; Zinc-finger double domain