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    dyf-5 Serine/threonine-protein kinase dyf-5 [ Caenorhabditis elegans ]

    Gene ID: 187442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dyf-5
    Official Full Name
    Serine/threonine-protein kinase dyf-5
    Primary source
    WormBase:WBGene00001121
    Locus tag
    CELE_M04C9.5
    See related
    AllianceGenome:WB:WBGene00001121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein serine/threonine kinase activity. Involved in cilium organization; protein localization; and regulation of non-motile cilium assembly. Located in several cellular components, including dendrite; neuronal cell body; and non-motile cilium. Is expressed in hypodermis; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in endocrine-cerebro-osteodysplasia syndrome; juvenile myoclonic epilepsy 10; and retinitis pigmentosa 62. Orthologous to several human genes including MAK (male germ cell associated kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dyf-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (9359067..9364238)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Pyroglutamyl-peptidase 1 Neighboring gene Wsv419 Neighboring gene ncRNA Neighboring gene Serine/threonine-protein phosphatase 4 regulatory subunit 1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map. Wicks SR, et al. Nat Genet, 2001 Jun. PMID 11381264
    2. Neurons dispose of hyperactive kinesin into glial cells for clearance. Xie C, et al. EMBO J, 2024 Jul. PMID 38806659, Free PMC Article
    3. The DYF-5 RCK and CDKL-1 CDKL5 kinases contribute differentially to shape distinct sensory neuron cilia morphologies in C. elegans. Maurya AK, et al. MicroPubl Biol, 2022. PMID 35996689, Free PMC Article
    4. xbx-4, a homolog of the Joubert syndrome gene FAM149B1, acts via the CCRK and RCK kinase cascade to regulate cilia morphology. Maurya AK, et al. Curr Biol, 2021 Dec 20. PMID 34731674, Free PMC Article
    5. The kinases male germ cell-associated kinase and cell cycle-related kinase regulate kinesin-2 motility in Caenorhabditis elegans neuronal cilia. Yi P, et al. Traffic, 2018 Jul. PMID 29655266

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DYF-5/MAK-dependent phosphorylation promotes ciliary tubulin unloading.
      Title: DYF-5/MAK-dependent phosphorylation promotes ciliary tubulin unloading.
    2. RNA editing restricts hyperactive ciliary kinases.
      Title: RNA editing restricts hyperactive ciliary kinases.
    3. In C. elegans, DYF-18/CCRK and DYF-5/MAK act in a cascade to generate the highly arborized cilia morphologies of the AWA olfactory neurons. Loss of kinase function results in dramatically elongated AWA cilia that lack branches.
      Title: A CCRK and a MAK Kinase Modulate Cilia Branching and Length via Regulation of Axonemal Microtubule Dynamics in Caenorhabditis elegans.
    4. dyf-5 stabilizes interaction between intraflagellar transport particles and OSM-3-kinesin in neuronal cilia.
      Title: The kinases male germ cell-associated kinase and cell cycle-related kinase regulate kinesin-2 motility in Caenorhabditis elegans neuronal cilia.
    5. DYF-5 plays a role in the undocking of kinesin II from intraflagellar transport (IFT) particles and in the docking of OSM-3 onto IFT particles.
      Title: Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary anterograde transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intraciliary anterograde transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of non-motile cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of non-motile cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase dyf-5
    NP_001129786.2
    • Confirmed by transcript evidence
    NP_492493.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9359067..9364238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136314.5 → NP_001129786.2  Serine/threonine-protein kinase dyf-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129786.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3WFY8, G5EG21
      Conserved Domains (1) summary
      cd07830
      Location:11 → 291
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    2. NM_060092.4 → NP_492493.2  Serine/threonine-protein kinase dyf-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492493.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3WFY8
      Conserved Domains (2) summary
      smart00220
      Location:11 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07830
      Location:11 → 291
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B3WFY8.2

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