U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    kcc-3 Amino acid permease;Potassium/chloride cotransporter 3 [ Caenorhabditis elegans ]

    Gene ID: 174212, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    kcc-3
    Official Full Name
    Amino acid permease;Potassium/chloride cotransporter 3
    Primary source
    WormBase:WBGene00019289
    Locus tag
    CELE_K02A2.3
    See related
    AllianceGenome:WB:WBGene00019289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable potassium:chloride symporter activity. Involved in microvillus organization. Located in apical plasma membrane. Is expressed in head; neuronal sheath cell; and tail. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See kcc-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    16
    Sequence:
    Chromosome: II; NC_003280.10 (7425939..7434282, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene Zinc metalloproteinase nas-7 Neighboring gene Serpentine receptor class delta-55 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class D (Delta) Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Neuron cilia restrain glial KCC-3 to a microdomain to regulate multisensory processing. Ray S, et al. Cell Rep, 2024 Mar 26. PMID 38421867, Free PMC Article
    2. A glial K(+) /Cl(-) cotransporter modifies temperature-evoked dynamics in Caenorhabditis elegans sensory neurons. Yoshida A, et al. Genes Brain Behav, 2016 Apr. PMID 26463820
    3. The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans. Tanis JE, et al. J Neurosci, 2009 Aug 12. PMID 19675228, Free PMC Article
    4. A Glial K/Cl Transporter Controls Neuronal Receptive Ending Shape by Chloride Inhibition of an rGC. Singhvi A, et al. Cell, 2016 May 5. PMID 27062922, Free PMC Article
    5. Glial regulators of ions and solutes required for specific chemosensory functions in Caenorhabditis elegans. Wang L, et al. iScience, 2022 Dec 22. PMID 36567707, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microvillus organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microvillus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Amino acid permease;Potassium/chloride cotransporter 3
    NP_001338797.1
    • Confirmed by transcript evidence
    NP_001338828.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7425939..7434282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001351920.4 → NP_001338797.1  Potassium/chloride cotransporter 3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09573
      Conserved Domains (1) summary
      cl27256
      Location:50 → 1070
      SLC12; Solute carrier family 12

    2. NM_001351919.3 → NP_001338828.1  Amino acid permease [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RC59
      Conserved Domains (1) summary
      cl27256
      Location:61 → 1081
      SLC12; Solute carrier family 12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09573.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools