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    sec-61.A Translocon Sec61/SecY plug domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178407, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sec-61.A
    Official Full Name
    Translocon Sec61/SecY plug domain-containing protein
    Primary source
    WormBase:WBGene00013311
    Locus tag
    CELE_Y57G11C.15
    See related
    AllianceGenome:WB:WBGene00013311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and post-translational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be part of Sec61 translocon complex. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sec-61.A in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (14822540..14825264, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein uS13 Neighboring gene Homolog of Hedgehog AcylTransferase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vitro analyses of the production and activity of secondary small interfering RNAs in C. elegans. Aoki K, et al. EMBO J, 2007 Dec 12. PMID 18007599, Free PMC Article
    2. Exploring transcriptional conservation between Ancylostoma caninum and Haemonchus contortus by oligonucleotide microarray and bioinformatic analyses. Cantacessi C, et al. Mol Cell Probes, 2009 Feb. PMID 18977290
    3. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
    4. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    5. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Translocon Sec61/SecY plug domain-containing protein
    NP_001255838.1
    • Confirmed by transcript evidence
    NP_001255839.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      14822540..14825264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268909.4 → NP_001255838.1  Translocon Sec61/SecY plug domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18239
      Conserved Domains (1) summary
      PTZ00219
      Location:1 → 468
      PTZ00219; Sec61 alpha subunit; Provisional

    2. NM_001268910.3 → NP_001255839.1  Translocon Sec61/SecY plug domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255839.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MU88
      Conserved Domains (1) summary
      PTZ00219
      Location:1 → 437
      PTZ00219; Sec61 alpha subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version

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