unc-22 Twitchin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-22
Official Full Name: Twitchin
Primary source: WormBase:WBGene00006759
Locus tag: CELE_ZK617.1
See related: AllianceGenome:WB:WBGene00006759
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including behavioral response to nicotine; positive regulation of sarcomere organization; and positive regulation of striated muscle contraction. Located in A band. Is expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-22 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 37

Sequence:: Chromosome: IV; NC_003282.8 (11972697..12011007, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Twitchin is activated by MAK-1. Twitchin may ba also regulated by the p38 MAP kinase pathway.
Title: Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK617.1 (e-PCR)
- UniSTS:317565

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to nicotine	IGI Inferred from Genetic Interaction more info	PubMed
involved_in behavioral response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of striated muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in A band	IDA Inferred from Direct Assay more info	PubMed
located_in A band	IEA Inferred from Electronic Annotation more info
is_active_in M band	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in sarcomere	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Twitchin

NP_001122835.2

Partially confirmed by transcript evidence

NP_001255601.1

Partially confirmed by transcript evidence

NP_001255602.1

Partially confirmed by transcript evidence

NP_001255603.2

Partially confirmed by transcript evidence

NP_001255604.1

Partially confirmed by transcript evidence

NP_001293974.1

Partially confirmed by transcript evidence

NP_001293975.1

Partially confirmed by transcript evidence

NP_502273.2

Partially confirmed by transcript evidence

NP_502274.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11972697..12011007 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069872.6 → NP_502273.2 Twitchin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502273.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23551

Conserved Domains (10) summary

cd00096
Location:5621 → 5690

Ig; Immunoglobulin domain

cd05748
Location:1493 → 1566

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:6407 → 6467

IGc2; Immunoglobulin C-2 Type

smart00220
Location:5942 → 6197

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:5707 → 5789

IG; Immunoglobulin

smart00410
Location:384 → 467

IG_like; Immunoglobulin like

cd00063
Location:4713 → 4806

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6266 → 6355

I-set; Immunoglobulin I-set domain

cd14114
Location:5939 → 6197

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3555 → 3628

Ig; Immunoglobulin domain
NM_001268672.3 → NP_001255601.1 Twitchin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255601.1

Status: REVIEWED

UniProtKB/TrEMBL

H2FLH2

Conserved Domains (10) summary

cd00096
Location:5709 → 5778

Ig; Immunoglobulin domain

cd05748
Location:1581 → 1654

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:6495 → 6555

IGc2; Immunoglobulin C-2 Type

smart00220
Location:6030 → 6285

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:5795 → 5877

IG; Immunoglobulin

smart00410
Location:384 → 467

IG_like; Immunoglobulin like

cd00063
Location:4801 → 4894

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6354 → 6443

I-set; Immunoglobulin I-set domain

cd14114
Location:6027 → 6285

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3643 → 3716

Ig; Immunoglobulin domain
NM_001268673.3 → NP_001255602.1 Twitchin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255602.1

Status: REVIEWED

UniProtKB/TrEMBL

H2FLH3

Conserved Domains (10) summary

cd00096
Location:5630 → 5699

Ig; Immunoglobulin domain

cd05748
Location:1502 → 1575

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:6416 → 6476

IGc2; Immunoglobulin C-2 Type

smart00220
Location:5951 → 6206

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:5716 → 5798

IG; Immunoglobulin

smart00410
Location:384 → 467

IG_like; Immunoglobulin like

cd00063
Location:4722 → 4815

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6275 → 6364

I-set; Immunoglobulin I-set domain

cd14114
Location:5948 → 6206

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3564 → 3637

Ig; Immunoglobulin domain
NM_001307046.3 → NP_001293975.1 Twitchin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293975.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ACT3

Conserved Domains (10) summary

cd00096
Location:5915 → 5984

Ig; Immunoglobulin domain

cd05748
Location:1787 → 1860

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:6701 → 6761

IGc2; Immunoglobulin C-2 Type

smart00220
Location:6236 → 6491

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:6001 → 6083

IG; Immunoglobulin

smart00410
Location:384 → 467

IG_like; Immunoglobulin like

cd00063
Location:5007 → 5100

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6560 → 6649

I-set; Immunoglobulin I-set domain

cd14114
Location:6233 → 6491

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3849 → 3922

Ig; Immunoglobulin domain
NM_001307045.3 → NP_001293974.1 Twitchin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293974.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AE24

Conserved Domains (10) summary

cd00096
Location:5924 → 5993

Ig; Immunoglobulin domain

cd05748
Location:1796 → 1869

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:6710 → 6770

IGc2; Immunoglobulin C-2 Type

smart00220
Location:6245 → 6500

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:6010 → 6092

IG; Immunoglobulin

smart00410
Location:384 → 467

IG_like; Immunoglobulin like

cd00063
Location:5016 → 5109

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6569 → 6658

I-set; Immunoglobulin I-set domain

cd14114
Location:6242 → 6500

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3858 → 3931

Ig; Immunoglobulin domain
NM_069873.6 → NP_502274.2 Twitchin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502274.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A3RMU0, D3YT57, D3YT58, Q23020, Q23550, Q23551, Q27232, Q7JN85

Conserved Domains (10) summary

cd00096
Location:5940 → 6009

Ig; Immunoglobulin domain

cd05748
Location:1812 → 1885

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:6726 → 6786

IGc2; Immunoglobulin C-2 Type

smart00220
Location:6261 → 6516

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:6026 → 6108

IG; Immunoglobulin

smart00410
Location:384 → 467

IG_like; Immunoglobulin like

cd00063
Location:5032 → 5125

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6585 → 6674

I-set; Immunoglobulin I-set domain

cd14114
Location:6258 → 6516

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3874 → 3947

Ig; Immunoglobulin domain
NM_001268674.4 → NP_001255603.2 Twitchin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255603.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23551

Conserved Domains (10) summary

cd00096
Location:5234 → 5303

Ig; Immunoglobulin domain

cd05748
Location:1106 → 1179

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:6020 → 6080

IGc2; Immunoglobulin C-2 Type

smart00220
Location:5555 → 5810

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:5320 → 5402

IG; Immunoglobulin

smart00410
Location:3752 → 3826

IG_like; Immunoglobulin like

cd00063
Location:4326 → 4419

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:5879 → 5968

I-set; Immunoglobulin I-set domain

cd14114
Location:5552 → 5810

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3168 → 3241

Ig; Immunoglobulin domain
NM_001129363.4 → NP_001122835.2 Twitchin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122835.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23551

Conserved Domains (10) summary

cd00096
Location:5401 → 5470

Ig; Immunoglobulin domain

cd05748
Location:1273 → 1346

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:6187 → 6247

IGc2; Immunoglobulin C-2 Type

smart00220
Location:5722 → 5977

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:5487 → 5569

IG; Immunoglobulin

smart00410
Location:3919 → 3993

IG_like; Immunoglobulin like

cd00063
Location:4493 → 4586

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6046 → 6135

I-set; Immunoglobulin I-set domain

cd14114
Location:5719 → 5977

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3335 → 3408

Ig; Immunoglobulin domain
NM_001268675.3 → NP_001255604.1 Twitchin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255604.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23551

Conserved Domains (10) summary

cd00096
Location:5217 → 5286

Ig; Immunoglobulin domain

cd05748
Location:1089 → 1162

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:6003 → 6063

IGc2; Immunoglobulin C-2 Type

smart00220
Location:5538 → 5793

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:5303 → 5385

IG; Immunoglobulin

smart00410
Location:3735 → 3809

IG_like; Immunoglobulin like

cd00063
Location:4309 → 4402

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:5862 → 5951

I-set; Immunoglobulin I-set domain

cd14114
Location:5535 → 5793

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3151 → 3224

Ig; Immunoglobulin domain