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    RND2 Rho family GTPase 2 [ Homo sapiens (human) ]

    Gene ID: 8153, updated on 27-Nov-2024

    Summary

    Official Symbol
    RND2provided by HGNC
    Official Full Name
    Rho family GTPase 2provided by HGNC
    Primary source
    HGNC:HGNC:18315
    See related
    Ensembl:ENSG00000108830 MIM:601555; AllianceGenome:HGNC:18315
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARHN; RHO7; RhoN
    Summary
    This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 14.7), testis (RPKM 13.8) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RND2 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43025231..43032041)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43883786..43890596)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41177248..41184058)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12233 Neighboring gene interferon induced protein 35 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8550 Neighboring gene vesicle amine transport 1 Neighboring gene Sharpr-MPRA regulatory region 8675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41195058-41195600 Neighboring gene BRCA1 DNA repair associated Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:41214996-41215531 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41224055-41224260 Neighboring gene ribosomal protein L21 pseudogene 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:41243136-41244335 Neighboring gene BRCA1 intronic recombination region Neighboring gene BRCA1 intron 2 regulatory region Neighboring gene BRCA1 promoter region Neighboring gene neighbor of BRCA1 lncRNA 2 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 29

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    rho-related GTP-binding protein RhoN
    Names
    CTD-3199J23.4
    GTP-binding protein Rho7
    ras homolog gene family, member N
    rho-related GTP-binding protein Rho7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005440.5NP_005431.1  rho-related GTP-binding protein RhoN

      See identical proteins and their annotated locations for NP_005431.1

      Status: REVIEWED

      Source sequence(s)
      AC135721, BC094842, BU687800, DB502558
      Consensus CDS
      CCDS11452.1
      UniProtKB/Swiss-Prot
      A8K2D4, O00690, O00734, P52198, Q5U0P6, Q99535
      UniProtKB/TrEMBL
      Q59EN3
      Related
      ENSP00000466680.1, ENST00000587250.4
      Conserved Domains (1) summary
      cd04173
      Location:7227
      Rnd2_Rho7; Rnd2/Rho7 GTPases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43025231..43032041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525316.2XP_011523618.1  rho-related GTP-binding protein RhoN isoform X1

      See identical proteins and their annotated locations for XP_011523618.1

      UniProtKB/TrEMBL
      Q59EN3
      Conserved Domains (2) summary
      smart00174
      Location:10182
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd04173
      Location:7227
      Rnd2_Rho7; Rnd2/Rho7 GTPases
    2. XM_011525317.3XP_011523619.1  rho-related GTP-binding protein RhoN isoform X2

      See identical proteins and their annotated locations for XP_011523619.1

      UniProtKB/TrEMBL
      Q59EN3
      Conserved Domains (1) summary
      cl38936
      Location:7199
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      43883786..43890596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317440.1XP_054173415.1  rho-related GTP-binding protein RhoN isoform X1

    2. XM_054317441.1XP_054173416.1  rho-related GTP-binding protein RhoN isoform X2