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    WHI4 Whi4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851302, updated on 9-Dec-2024

    Summary

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    Official Symbol
    WHI4
    Official Full Name
    Whi4p
    Primary source
    SGD:S000002383
    Locus tag
    YDL224C
    See related
    AllianceGenome:SGD:S000002383; FungiDB:YDL224C; VEuPathDB:YDL224C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable mRNA binding activity. Involved in mRNA destabilization and regulation of cell size. Located in cytoplasm. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor) and RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See WHI4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (54397..56346, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein GCS1 Neighboring gene septin SHS1 Neighboring gene Hbt1p Neighboring gene Fmp45p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of the yeast RNA-binding protein Whi3 on the half-life and abundance of CLN3 mRNA and other targets. Cai Y, et al. PLoS One, 2013. PMID 24386402, Free PMC Article
    2. Hypersensitive SSY1 mutations negatively influence transition to quiescence in yeast Saccharomyces cerevisiae. Marek A, et al. Yeast, 2021 Jan. PMID 33179371
    3. Isolation and characterization of WHI3, a size-control gene of Saccharomyces cerevisiae. Nash RS, et al. Genetics, 2001 Apr. PMID 11290704, Free PMC Article
    4. Conserved patterns of protein interaction in multiple species. Sharan R, et al. Proc Natl Acad Sci U S A, 2005 Feb 8. PMID 15687504, Free PMC Article
    5. The DNA damage response pathway contributes to the stability of chromosome III derivatives lacking efficient replicators. Theis JF, et al. PLoS Genet, 2010 Dec 2. PMID 21151954, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA destabilization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Whi4p
    NP_010057.1
    • Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      54397..56346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180284.1 → NP_010057.1  TPA: Whi4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010057.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRD1, Q07655
      UniProtKB/TrEMBL
      A6ZXB0, B5VF53, C7GSV4, C8Z6P5, N1P666
      Conserved Domains (1) summary
      cd12245
      Location:531 → 624
      RRM_scw1_like; RNA recognition motif (RRM) found in yeast cell wall integrity protein scw1 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07655.1

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