PTP1 tyrosine protein phosphatase PTP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PTP1
Official Full Name: tyrosine protein phosphatase PTP1
Primary source: SGD:S000002389
Locus tag: YDL230W
See related: AllianceGenome:SGD:S000002389; FungiDB:YDL230W; VEuPathDB:YDL230W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein tyrosine phosphatase activity. Involved in invasive growth in response to glucose limitation and pseudohyphal growth. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; artery disease (multiple); autoimmune disease (multiple); diabetes mellitus (multiple); and graft-versus-host disease. Orthologous to several human genes including PTPN1 (protein tyrosine phosphatase non-receptor type 1) and PTPN7 (protein tyrosine phosphatase non-receptor type 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PTP1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (42700..43707)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ptp1 and PP2ARts1 work redundantly with Mih1 to regulate Cdk1-Y19 dephosphorylation
Title: Redundant Regulation of Cdk1 Tyrosine Dephosphorylation in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pseudohyphal growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: tyrosine protein phosphatase PTP1

NP_010051.1

EC 3.1.3.48

Phosphotyrosine-specific protein phosphatase; dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

42700..43707

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180290.1 → NP_010051.1 TPA: tyrosine protein phosphatase PTP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010051.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRC6, P25044

UniProtKB/TrEMBL

A6ZXA4, B5VF49, C7GJP9, C8Z6N9, G2WBT9, N1P606

Conserved Domains (1) summary

COG5599
Location:1 → 335

COG5599; Protein tyrosine phosphatase [Signal transduction mechanisms]